S42 Correlation of measurement of small airways indices in a population of firefighters
File(s)
Accepted version
Author(s)
Feary, J
Kabir, T
Schofield, S
Cullinan, P
Type
Conference Paper
Abstract
Background Small airways damage is a plausible response to fire smoke inhalation. In the UK, periodic respiratory health surveillance is carried out using spirometry. Previous studies have suggested the use of impulse oscillometry (IOS) may identify small airways dysfunction in firefighters even in the context of normal spirometry values and it is hypothesised that this may predict future development of asthma or COPD.
Methods We measured pre and post-bronchodilator spirometry and IOS using ERS/ATS guidelines on the first 203 individuals recruited to a cohort study of firefighters (Grenfell Firefighter Study). We defined significant bronchodilator response as an improvement in forced expiratory volume in one second (FEV1) of 12% and 200mls following administration of inhaled bronchodilator. We also collected information on smoking and self-reported breathlessness using the Dyspnoea-12 questionnaire (maximum score of 36) and explored correlations between different measurements of small airways function.
Results The majority of individuals were male, with a mean age of 45 years; 140 (69%) had never smoked and 12 (6%) had a more than 20 pack year history of smoking. Overall, 32 (16%) had a history of asthma (ever), 15 (8%) had evidence of significant bronchodilator reversibility and 3 (2%) were taking asthma treatment. The majority (73%) reported no breathless (Dyspnoea-12 score of zero). The mean percentage predicted pre-bronchodilator FEV1, forced vital capacity (FVC) and forced expiratory flow at 25–75% of FVC (FEF25–75) were 98%, 102% and 92% respectively using GLI reference equations. The correlation between FEF25–75 and frequency dependence of resistance (R5-R20) was -0.22 (-0.35 to -0.08).
Methods We measured pre and post-bronchodilator spirometry and IOS using ERS/ATS guidelines on the first 203 individuals recruited to a cohort study of firefighters (Grenfell Firefighter Study). We defined significant bronchodilator response as an improvement in forced expiratory volume in one second (FEV1) of 12% and 200mls following administration of inhaled bronchodilator. We also collected information on smoking and self-reported breathlessness using the Dyspnoea-12 questionnaire (maximum score of 36) and explored correlations between different measurements of small airways function.
Results The majority of individuals were male, with a mean age of 45 years; 140 (69%) had never smoked and 12 (6%) had a more than 20 pack year history of smoking. Overall, 32 (16%) had a history of asthma (ever), 15 (8%) had evidence of significant bronchodilator reversibility and 3 (2%) were taking asthma treatment. The majority (73%) reported no breathless (Dyspnoea-12 score of zero). The mean percentage predicted pre-bronchodilator FEV1, forced vital capacity (FVC) and forced expiratory flow at 25–75% of FVC (FEF25–75) were 98%, 102% and 92% respectively using GLI reference equations. The correlation between FEF25–75 and frequency dependence of resistance (R5-R20) was -0.22 (-0.35 to -0.08).
Date Issued
2021-11-08
Date Acceptance
2021-11-01
Citation
Thorax, 2021, 76, pp.A31-A31
ISSN
0040-6376
Publisher
BMJ Publishing Group
Start Page
A31
End Page
A31
Journal / Book Title
Thorax
Volume
76
Copyright Statement
© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ. This article has been accepted for publication in Thorax following peer review. The definitive copyedited, typeset version Feary J, Kabir T, Schofield S, et alS42 Correlation of measurement of small airways indices in a population of firefightersThorax 2021;76:A31 is available online at: http://dx.doi.org/10.1136/thorax-2021-BTSabstracts.48
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000721358900049&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Source
British Thoracic Society Winter Meeting 2021
Subjects
Science & Technology
Life Sciences & Biomedicine
Respiratory System
Publication Status
Published
Start Date
2021-11-24
Finish Date
2021-11-26
Coverage Spatial
Online
Date Publish Online
2021-11-08