Inflammatory markers and risk of epithelial ovarian cancer by tumor subtypes: the EPIC cohort
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Background: Evidence suggests an etiologic role for inflammation in ovarian carcinogenesis and heterogeneity between tumor subtypes and anthropometric indices. Prospective studies on circulating inflammatory markers and epithelial invasive ovarian cancer (EOC) have predominantly investigated overall risk; data characterizing risk by tumor characteristics (histology, grade, stage, dualistic model of ovarian carcinogenesis) and anthropometric indices are sparse.
Methods: We conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate C-reactive protein (CRP), IL6, and EOC risk by tumor characteristics. A total of 754 eligible EOC cases were identified; two controls (n = 1,497) were matched per case. We used multivariable conditional logistic regression to assess associations.
Results: CRP and IL6 were not associated with overall EOC risk. However, consistent with prior research, CRP >10 versus CRP ≤1 mg/L was associated with higher overall EOC risk [OR, 1.67 (1.03–2.70)]. We did not observe significant associations or heterogeneity in analyses by tumor characteristics. In analyses stratified by waist circumference, inflammatory markers were associated with higher risk among women with higher waist circumference; no association was observed for women with normal waist circumference [e.g., IL6: waist ≤80: ORlog2, 0.97 (0.81–1.16); waist >88: ORlog2, 1.78 (1.28–2.48), Pheterogeneity ≤ 0.01].
Conclusions: Our data suggest that high CRP is associated with increased risk of overall EOC, and that IL6 and CRP may be associated with EOC risk among women with higher adiposity.
Impact: Our data add to global evidence that ovarian carcinogenesis may be promoted by an inflammatory milieu.
Methods: We conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate C-reactive protein (CRP), IL6, and EOC risk by tumor characteristics. A total of 754 eligible EOC cases were identified; two controls (n = 1,497) were matched per case. We used multivariable conditional logistic regression to assess associations.
Results: CRP and IL6 were not associated with overall EOC risk. However, consistent with prior research, CRP >10 versus CRP ≤1 mg/L was associated with higher overall EOC risk [OR, 1.67 (1.03–2.70)]. We did not observe significant associations or heterogeneity in analyses by tumor characteristics. In analyses stratified by waist circumference, inflammatory markers were associated with higher risk among women with higher waist circumference; no association was observed for women with normal waist circumference [e.g., IL6: waist ≤80: ORlog2, 0.97 (0.81–1.16); waist >88: ORlog2, 1.78 (1.28–2.48), Pheterogeneity ≤ 0.01].
Conclusions: Our data suggest that high CRP is associated with increased risk of overall EOC, and that IL6 and CRP may be associated with EOC risk among women with higher adiposity.
Impact: Our data add to global evidence that ovarian carcinogenesis may be promoted by an inflammatory milieu.
Date Issued
2015-04-08
Date Acceptance
2015-03-20
Citation
Cancer Epidemiology, Biomarkers and Prevention, 2015, 24 (6), pp.951-961
ISSN
1055-9965
Publisher
American Association for Cancer Research
Start Page
951
End Page
961
Journal / Book Title
Cancer Epidemiology, Biomarkers and Prevention
Volume
24
Issue
6
Copyright Statement
© 2015 American Association for Cancer Research.
Sponsor
Imperial College Trust
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000357425200009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
P47328
Subjects
Science & Technology
Life Sciences & Biomedicine
Oncology
Public, Environmental & Occupational Health
C-REACTIVE PROTEIN
BREAST-CANCER
ANTHROPOMETRIC MEASURES
MOLECULAR PATHOGENESIS
PHYSICAL-ACTIVITY
CENTRAL ADIPOSITY
BODY-SIZE
WOMEN
OBESITY
SERUM
Adenocarcinoma, Clear Cell
Adenocarcinoma, Mucinous
Adult
Aged
Biomarkers, Tumor
Case-Control Studies
Cystadenocarcinoma, Serous
Endometrial Neoplasms
Female
Follow-Up Studies
Humans
Inflammation
Inflammation Mediators
Middle Aged
Neoplasm Grading
Neoplasm Invasiveness
Neoplasm Staging
Ovarian Neoplasms
Prognosis
Prospective Studies
Epidemiology
11 Medical And Health Sciences
Publication Status
Published