Oxidized LDL and anti-oxidized LDL antibodies in atherosclerosis - novel insights and future directions in diagnosis and therapy
File(s)Manuscript review 2 FINAL.docx (117.28 KB)
Accepted version
Author(s)
Hartley, adam
Dorian, Haskard
Khamis, RYJ
Type
Journal Article
Abstract
We provide an up-to-date overview of current topics surrounding oxidized low-density lipoprotein (oxLDL) and its related antibodies in the quest to better identify the individuals at risk of cardiovascular disease and atherosclerotic plaques with unfavorable characteristics. We discuss the potential of oxLDL and anti-oxLDL antibodies as serum biomarkers of cardiovascular disease and emerging studies examining the targeting of arterial oxLDL for imaging and therapeutic delivery.
Date Issued
2019-01
Date Acceptance
2018-05-27
Citation
Trends in Cardiovascular Medicine, 2019, 29 (1), pp.22-26
ISSN
1050-1738
Publisher
Elsevier
Start Page
22
End Page
26
Journal / Book Title
Trends in Cardiovascular Medicine
Volume
29
Issue
1
Copyright Statement
© 2018 Elsevier Inc. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
National Institute for Health Research
Imperial College Healthcare Charity
British Heart Foundation
Imperial College Healthcare NHS Trust- BRC Funding
Identifier
https://www.sciencedirect.com/science/article/pii/S1050173818300835?via%3Dihub
Grant Number
RDB02 79560
5118
FS/17/16/32560
RDB02
Subjects
Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
Oxidized low-density lipoprotein
Atherosclerosis
Vulnerable plaque
LOW-DENSITY-LIPOPROTEIN
OXIDATION-SPECIFIC EPITOPES
APOLIPOPROTEIN B-100
IMMUNE-COMPLEXES
CARDIOVASCULAR EVENTS
IGM AUTOANTIBODIES
MDA-LDL
CORONARY
BIOMARKERS
STROKE
Atherosclerosis
Oxidized low-density lipoprotein
Vulnerable plaque
Animals
Antibodies
Arteries
Atherosclerosis
Biomarkers
Humans
Immunization
Lipoproteins, LDL
Molecular Imaging
Plaque, Atherosclerotic
Predictive Value of Tests
Prognosis
Vaccines
Arteries
Animals
Humans
Lipoproteins, LDL
Vaccines
Antibodies
Prognosis
Immunization
Predictive Value of Tests
Atherosclerosis
Molecular Imaging
Plaque, Atherosclerotic
Biomarkers
1102 Cardiorespiratory Medicine and Haematology
Cardiovascular System & Hematology
Publication Status
Published
Date Publish Online
2018-06-04