Cellular and molecular mechanisms of asthma and COPD
File(s)
Author(s)
Barnes, PJ
Type
Journal Article
Abstract
Asthma and chronic obstructive pulmonary disease (COPD) both cause airway obstruction and are associated with chronic inflammation of the airways. However, the nature and sites of the inflammation differ between these diseases, resulting in different pathology, clinical manifestations and response to therapy. In this review, the inflammatory and cellular mechanisms of asthma and COPD are compared and the differences in inflammatory cells and profile of inflammatory mediators are highlighted. These differences account for the differences in clinical manifestations of asthma and COPD and their response to therapy. Although asthma and COPD are usually distinct, there are some patients who show an overlap of features, which may be explained by the coincidence of two common diseases or distinct phenotypes of each disease. It is important to better understand the underlying cellular and molecular mechanisms of asthma and COPD in order to develop new treatments in areas of unmet need, such as severe asthma, curative therapy for asthma and effective anti-inflammatory treatments for COPD.
Date Issued
2017-06-28
Date Acceptance
2017-03-01
Citation
CLINICAL SCIENCE, 2017, 131 (13), pp.1541-1558
ISSN
0143-5221
Publisher
PORTLAND PRESS LTD
Start Page
1541
End Page
1558
Journal / Book Title
CLINICAL SCIENCE
Volume
131
Issue
13
Copyright Statement
© 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000405988900014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Medicine, Research & Experimental
Research & Experimental Medicine
OBSTRUCTIVE PULMONARY-DISEASE
NLRP3 INFLAMMASOME ACTIVATION
PLACEBO-CONTROLLED TRIAL
SMALL-AIRWAY OBSTRUCTION
INNATE LYMPHOID-CELLS
GROWTH-FACTOR
ALVEOLAR MACROPHAGES
OXIDATIVE STRESS
BRONCHIAL-MUCOSA
EPITHELIAL-CELLS
cytokines/2
inflammation
inflammatory cells
Asthma
Cytokines
Dendritic Cells
Humans
Inflammasomes
Inflammation
Inflammation Mediators
Leukocytes
Macrophages
Mast Cells
Oxidative Stress
Pulmonary Disease, Chronic Obstructive
11 Medical And Health Sciences
Cardiovascular System & Hematology
Publication Status
Published