Locally recurrent rectal cancer according to a standardized MRI classification system: a systematic review of the literature
File(s)
Accepted version
Author(s)
Kontovounisios, Christos
Type
Journal Article
Abstract
(1) Background: Classification of Locally recurrent rectal cancer (LRRC) is not currently stand-ardized. The aim of this review was to evaluate pelvic LRRC according to the Beyond TME (BTME) classification system and to consider commonly associated primary tumour characteristics. (2) Methods: A systematic review of the literature prior to April 2020 was performed through elec-tronic searches of the Science Citation Index Expanded, EMBASE, MEDLINE and CENTRAL da-tabases. The primary outcome was to assess location and frequency of previously classified pelvic LRRC and translate this information into the BTME system. Secondary outcomes were assessing primary tumour characteristics. (3) Results: A total of 58 eligible studies classified 4558 sites of LRRC, most commonly found in the central compartment (18%), following anterior resection (44%), in patients with an ‘advanced’ primary tumour (63%) and following neoadjuvant radio-therapy (29%). Most patients also classified had a low rectal primary tumour. Lymph node status of the primary tumour leading to LRRC was comparable, with 52% node positive versus 48% node negative tumours. (4) Conclusion: This review evaluates the largest number of LRRCs to date using a single classification system. It has also highlighted the need for standardized reporting in order to optimise perioperative treatment planning.
Date Acceptance
2022-06-15
Citation
Journal of Clinical Medicine, 11 (12)
ISSN
2077-0383
Publisher
MDPI AG
Journal / Book Title
Journal of Clinical Medicine
Volume
11
Issue
12
Copyright Statement
© 2022 by the authors. Submitted for possible open access publication under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
https://www.mdpi.com/2077-0383/11/12/3511
Subjects
Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
locally recurrent rectal cancer (LRRC)
rectal cancer
BTME classification
TOTAL MESORECTAL EXCISION
LOW ANTERIOR RESECTION
5-YEAR FOLLOW-UP
PELVIC RECURRENCE
LOCOREGIONAL RECURRENCE
CURATIVE RESECTION
PROGNOSTIC-FACTORS
RADIATION-THERAPY
NEOADJUVANT CHEMORADIOTHERAPY
CIRCUMFERENTIAL MARGIN
BTME classification
locally recurrent rectal cancer (LRRC)
rectal cancer
1103 Clinical Sciences
Publication Status
Published