Resistance to ceftazidime/Avibactam plus meropenem/Vaborbactam when both are used together is achieved in four steps in metallo-β-lactamase-negative klebsiella pneumoniae
Author(s)
Dulyayangkul, Punyawee
Douglas, Edward JA
Lastovka, Filip
Avison, Matthew B
Type
Journal Article
Abstract
<jats:p>
Serine β-lactamases are dominant causes of β-lactam resistance in
<jats:named-content content-type="genus-species">Klebsiella pneumoniae</jats:named-content>
isolates. Recently, this has driven clinical deployment of the β-lactam–β-lactamase inhibitor pairs ceftazidime/avibactam and meropenem/vaborbactam. We show that four steps, i.e.,
<jats:italic>ompK36</jats:italic>
and
<jats:italic>ramR</jats:italic>
mutation plus carriage of OXA-232 and KPC-3-D178Y variant β-lactamases, confer ceftazidime/avibactam and meropenem/vaborbactam resistance when both pairs are used together.
</jats:p>
Serine β-lactamases are dominant causes of β-lactam resistance in
<jats:named-content content-type="genus-species">Klebsiella pneumoniae</jats:named-content>
isolates. Recently, this has driven clinical deployment of the β-lactam–β-lactamase inhibitor pairs ceftazidime/avibactam and meropenem/vaborbactam. We show that four steps, i.e.,
<jats:italic>ompK36</jats:italic>
and
<jats:italic>ramR</jats:italic>
mutation plus carriage of OXA-232 and KPC-3-D178Y variant β-lactamases, confer ceftazidime/avibactam and meropenem/vaborbactam resistance when both pairs are used together.
</jats:p>
Date Issued
2020-09-01
Date Acceptance
2020-07-07
Citation
Antimicrobial Agents and Chemotherapy, 2020, 64 (10)
ISSN
0066-4804
Publisher
American Society for Microbiology
Journal / Book Title
Antimicrobial Agents and Chemotherapy
Volume
64
Issue
10
Copyright Statement
Copyright © American Society for Biochemistry and Molecular Biology. This research was originally published in Antimicrobial Agents and Chemotherapy. Edward J. Douglas. Resistance to Ceftazidime/Avibactam plus Meropenem/Vaborbactam When Both Are Used Together Is Achieved in Four Steps in Metallo-β-Lactamase-Negative Klebsiella pneumoniae. ASM Journals. 2020; Vol 64: No10.
License URL
Identifier
10.1128/AAC
Publication Status
Published
Article Number
e00409-20
Date Publish Online
2020-07-13