Genetic determinants of coping, resilience and self-esteem in schizophrenia suggest a primary role for social factors and hippocampal neurogenesis
File(s)
Accepted version
Author(s)
Mazzarotto, Francesco
Monteleone, Palmiero
Minelli, Alessandra
Mattevi, Stefania
Cascino, Giammarco
Type
Journal Article
Abstract
Schizophrenia is a severe psychiatric disorder, associated with a reduction in life expectancy of 15–20 years. Available treatments are at least partially effective in most affected individuals, and personal resources such as resilience (successful adaptation despite adversity) and coping abilities (strategies used to deal with stressful or threatening situations), are important determinants of disease outcomes and long-term sustained recovery. Published findings support the existence of a genetic background underlying resilience and coping, with variable heritability estimates. However, genome-wide analyses concerning the genetic determinants of these personal resources, especially in the context of schizophrenia, are lacking. Here, we performed a genome-wide association study coupled with accessory analyses to investigate potential genetic determinants of resilience, coping and self-esteem in 490 schizophrenia patients. Results revealed a complex genetic background partly overlapping with that of neuroticism, worry and schizophrenia itself and support the importance of social aspects in shaping these psychological constructs. Hippocampal neurogenesis and lipid metabolism appear to be potentially relevant biological underpinnings, and specific miRNAs such as miR-124 and miR-137 may warrant further studies as potential biomarkers. In conclusion, this study represents an important first step in the identification of genetic and biological correlates shaping resilience, coping resources and self-esteem in schizophrenia.
Date Issued
2024-10-01
Date Acceptance
2024-07-24
Citation
Psychiatry Research, 2024, 340
ISSN
0165-1781
Publisher
Elsevier
Journal / Book Title
Psychiatry Research
Volume
340
Copyright Statement
Copyright © 2024 Elsevier B.V. This is the author’s accepted manuscript made available under a CC-BY licence in accordance with Imperial’s Research Publications Open Access policy (www.imperial.ac.uk/oa-policy)
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/39096746
PII: S0165-1781(24)00392-5
Subjects
Common genetic variants
GENOME-WIDE ASSOCIATION
Genome-wide association study
Life Sciences & Biomedicine
Lipid metabolism
METAANALYSIS
Micro-RNAs
MICRORNAS
NETWORKS
Neuroticism
PEOPLE
Personal resources
PERSONAL RESOURCES
Pleiotropy
POSTTRAUMATIC-STRESS-DISORDER
Psychiatry
RECOVERY
RISK
Science & Technology
SYMPTOMS
Worry
Publication Status
Published
Coverage Spatial
Ireland
Article Number
116107
Date Publish Online
2024-07-30