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Immunoglobulin Free Light Chains in the Pathogenesis of Lung Disorders.
File(s)
1082-5104-7-PB.pdf (426.07 KB)
Published version
Author(s)
Mortaz, E
Adcock, IM
Jamaati, H
Khosravi, A
Movassaghi, M
Type
Journal Article
Abstract
Inflammation is an important component of numerous cancers and chronic diseases and many inflammatory mediators have been shown to have potential prognostic roles. Tumor-infiltrating mast cells can promote tumor growth and angiogenesis, but the mechanism of mast cell activation is unclear. Early studies have shown that immunoglobulin free light chains (FLC) can trigger mast cell activation in an antigen-specific manner. Increased expression of FLC is observed within the stroma of many human cancers including those of breast, colon, lung, pancreas, kidney, and skin. These overexpressed FLCs are co-localized to areas of mast cell infiltration. Importantly, FLC expression is associated with basal-like cancers with an aggressive phenotype. Moreover, FLC is expressed in areas of inflammatory cell infiltration and its expression is significantly associated with poor clinical outcome. In addition, serum and bronchoalveolar fluid FLC concentrations are increased in patients with idiopathic pulmonary fibrosis (IPF) and hypersensitivity pneumonitis (HP) compared to control subjects. In this review, we provide an update on the role of FLC in the pathogenesis of several lung disorders and indicate how this may contribute to new therapeutic opportunities.
Date Issued
2017-08-12
Date Acceptance
2017-03-27
Citation
Iranian Journal Of Allergy, Asthma and Immunology, 2017, 16 (4), pp.282-288
URI
DOI
ISSN
1735-1502
Publisher
Tehran University of Medical Sciences
Start Page
282
End Page
288
Journal / Book Title
Iranian Journal Of Allergy, Asthma and Immunology
Volume
16
Issue
4
Copyright Statement
This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
License URL
Sponsor
Wellcome Trust
Grant Number
093080/Z/10/Z
Subjects
Asthma
Chronic obstructive lungs disease (COPD)
Free light chain
Hypersensitivity pneumonitis (HP)
Idiopathic pulmonary fibrosis (IPF)
Lung cancer
Publication Status
Published