Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
File(s)
Accepted version
Supporting information
Author(s)
Type
Journal Article
Abstract
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells.
Date Issued
2019-01-01
Date Acceptance
2018-10-31
Citation
Nature Genetics, 2019, 51 (1), pp.51-62
ISSN
1061-4036
Publisher
Nature Research
Start Page
51
End Page
62
Journal / Book Title
Nature Genetics
Volume
51
Issue
1
Copyright Statement
© 2018 The Author(s), under exclusive licence to Springer Nature America, Inc.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000454108800013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
GENOME-WIDE ASSOCIATION
AUTOSOMAL-DOMINANT HYPERTENSION
SOLUBLE GUANYLYL CYCLASE
PULSE PRESSURE
PARTITIONING HERITABILITY
GLOBAL BURDEN
MEAN ARTERIAL
IDENTIFIES 8
GENE
LOCI
Publication Status
Published
Date Publish Online
2018-12-21