The importance of dyslipidaemia in the pathogenesis of cardiovascular disease in people with diabetes
File(s)Revised Manuscript.docx (1005.68 KB)
Accepted version
Author(s)
Gonna, Hanney
Ray, Kausik K
Type
Journal Article
Abstract
Atherosclerotic cardiovascular events are the leading cause of mortality and morbidity in those with diabetes. A key contributor to the development of atherosclerosis in this population is the presence of a particularly atherogenic lipid profile often referred to as ‘Diabetic Dyslipidemia’. This profile is characterized by elevated triglycerides, triglyceride‐rich lipoproteins, small dense LDL particles, and reduced HDL levels. This article reviews the underlying aetiology and pathophysiology of this dyslipidaemia and atherosclerosis in those with diabetes, provides insights from epidemiological and genetic studies, and current cardiovascular risk reducing interventions including novel therapies such as PCSK‐9 inhibitors.
Date Issued
2019-04-01
Date Acceptance
2019-03-06
Citation
Diabetes, Obesity and Metabolism, 2019, 21 (S1), pp.6-16
ISSN
1462-8902
Publisher
Wiley
Start Page
6
End Page
16
Journal / Book Title
Diabetes, Obesity and Metabolism
Volume
21
Issue
S1
Copyright Statement
© 2019 John Wiley & Sons Ltd. This is the accepted version of the following article, which has been published in final form at https://onlinelibrary.wiley.com/doi/full/10.1111/dom.13691
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000465249100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
cardiovascular disease
diabetes complications
CORONARY-HEART-DISEASE
PCSK9 INHIBITOR EVOLOCUMAB
TRIGLYCERIDE-RICH LIPOPROTEINS
LIPID-LOWERING EFFICACY
OF-FUNCTION MUTATIONS
ALL-CAUSE MORTALITY
RISK-FACTORS
BLOOD-PRESSURE
APOLIPOPROTEIN-B
HDL-CHOLESTEROL
Publication Status
Published
Date Publish Online
2019-04-19