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Metabolic phenotyping for discovery of urinary biomarkers of diet, xenobiotics and blood pressure in the INTERMAP Study: An overview
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INTERMAP metabolic phenotyping paper (resubmission) full version.pdf | Accepted version | 1.13 MB | Adobe PDF | View/Open |
Title: | Metabolic phenotyping for discovery of urinary biomarkers of diet, xenobiotics and blood pressure in the INTERMAP Study: An overview |
Authors: | Chan, Q Loo, RL Ebbels, TMD Van Horn, L Daviglus, ML Stamler, J Nicholson, JK Holmes, E Elliott, P |
Item Type: | Journal Article |
Abstract: | The aetiopathogenesis of cardiovascular diseases (CVD) is multifactorial. Adverse blood pressure (BP) is a major independent risk factor for epidemic CVD affecting about 40% of the adult population worldwide and resulting in significant morbidity and mortality. Metabolic phenotyping of biological fluids has proven its application in characterisin g low molecule weight metabolites providing novel insights into gene -environmental -gut microbiome interaction in relations to a disease state. In this review, we synthesi s e key results from the International Study of Macro/Micronutrients and Blood Pressure (INTERMAP) Study, a cross - sectional epidemiological study of 4,680 men and women aged 40 -59 years from Japan, the People’s Republic of China, the United Kingdom, and the United States. We describe the advancements we have made on: 1) analytical techniques for high throughput metabolic phenotyping; 2) statistical analyses for biomarker identification; 3) discovery of unique food - specific biomarkers; and 4) application of metabolome -wide association (MWA) studies to gain a better understanding into the molecular mechanisms of cross cultural and regional BP differences. |
Issue Date: | 22-Dec-2016 |
Date of Acceptance: | 7-Oct-2016 |
URI: | http://hdl.handle.net/10044/1/41287 |
DOI: | https://dx.doi.org/10.1038/hr.2016.164 |
ISSN: | 1348-4214 |
Publisher: | Nature Publishing Group |
Start Page: | 336 |
End Page: | 345 |
Journal / Book Title: | Hypertension Research |
Volume: | 40 |
Copyright Statement: | Copyright © 2016, Rights Managed by Nature Publishing Group |
Sponsor/Funder: | National Institutes of Health National Institute for Health Research Imperial College Healthcare NHS Trust- BRC Funding National Institutes of Health Medical Research Council (MRC) |
Funder's Grant Number: | 0600 370 D330 1362 NF-SI-0611-10136 RDC01 79560 60024563 ICL MC_PC_12025 |
Keywords: | Science & Technology Life Sciences & Biomedicine Peripheral Vascular Disease Cardiovascular System & Cardiology blood pressure metabolic phenotyping metabonomics molecular epidemiology OPTIMIZED STATISTICAL APPROACH SYMPATHETIC-NERVOUS-SYSTEM CHRONIC KIDNEY-DISEASE REPUBLIC-OF-CHINA MAGNETIC-RESONANCE WIDE ASSOCIATION RISK-FACTORS H-1-NMR SPECTROSCOPY NMR-SPECTROSCOPY GUT MICROBIOTA 1103 Clinical Sciences 1102 Cardiovascular Medicine And Haematology Cardiovascular System & Hematology |
Publication Status: | Published |
Appears in Collections: | Department of Surgery and Cancer |