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Metabolomics in toxicology and preclinical research

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Title: Metabolomics in toxicology and preclinical research
Authors: Ramirez, T
Daneshian, M
Kamp, H
Bois, FY
Clench, MR
Coen, M
Donley, B
Fischer, SM
Ekman, DR
Fabian, E
Guillou, C
Heuer, J
Hogberg, HT
Jungnickel, H
Keun, HC
Krennrich, G
Krupp, E
Luch, A
Noor, F
Peter, E
Riefke, B
Seymour, M
Skinner, N
Smirnova, L
Verheij, E
Wagner, S
Hartung, T
Van Ravenzwaay, B
Leist, M
Item Type: Journal Article
Abstract: Metabolomics, the comprehensive analysis of metabolites in a biological system, provides detailed information about the biochemical/physiological status of a biological system, and about the changes caused by chemicals. Metabolomics analysis is used in many fields, ranging from the analysis of the physiological status of genetically modified organisms in safety science to the evaluation of human health conditions. In toxicology, metabolomics is the -omics discipline that is most closely related to classical knowledge of disturbed biochemical pathways. It allows rapid identification of the potential targets of a hazardous compound. It can give information on target organs and often can help to improve our understanding regarding the mode-of-action of a given compound. Such insights aid the discovery of biomarkers that either indicate pathophysiological conditions or help the monitoring of the efficacy of drug therapies. The first toxicological applications of metabolomics were for mechanistic research, but different ways to use the technology in a regulatory context are being explored. Ideally, further progress in that direction will position the metabolomics approach to address the challenges of toxicology of the 21st century. To address these issues, scientists from academia, industry, and regulatory bodies came together in a workshop to discuss the current status of applied metabolomics and its potential in the safety assessment of compounds. We report here on the conclusions of three working groups addressing questions regarding 1) metabolomics for in vitro studies 2) the appropriate use of metabolomics in systems toxicology, and 3) use of metabolomics in a regulatory context.
Issue Date: 1-May-2013
Date of Acceptance: 1-May-2013
URI: http://hdl.handle.net/10044/1/79276
DOI: 10.14573/altex.2013.2.209
ISSN: 0946-7785
Publisher: Springer
Start Page: 209
End Page: 225
Journal / Book Title: ALTEX : Alternatives to Animal Experimentation
Volume: 30
Issue: 2
Copyright Statement: © 2013 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). Articles are distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is appropriately cited (CC-BY). Copyright on any article in ALTEX is retained by the author(s).
Sponsor/Funder: Medical Research Council (MRC)
Funder's Grant Number: G0801056B
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, Research & Experimental
Research & Experimental Medicine
metabolomics
toxicology
preclinical research
regulatory toxicology
CELL-CULTURE PRACTICE
IN-VITRO
DEVELOPMENTAL TOXICITY
SYSTEMS TOXICOLOGY
MODEL SYSTEM
TASK-FORCE
FOOD
BIOMARKERS
THOUGHT
METABOLISM
Animals
Humans
Metabolomics
Models, Biological
Predictive Value of Tests
Reproducibility of Results
Toxicity Tests
Animals
Humans
Reproducibility of Results
Predictive Value of Tests
Toxicity Tests
Models, Biological
Metabolomics
Science & Technology
Life Sciences & Biomedicine
Medicine, Research & Experimental
Research & Experimental Medicine
metabolomics
toxicology
preclinical research
regulatory toxicology
CELL-CULTURE PRACTICE
IN-VITRO
DEVELOPMENTAL TOXICITY
SYSTEMS TOXICOLOGY
MODEL SYSTEM
TASK-FORCE
FOOD
BIOMARKERS
THOUGHT
METABOLISM
07 Agricultural and Veterinary Sciences
11 Medical and Health Sciences
Toxicology
Publication Status: Published
Online Publication Date: 2013-05-01
Appears in Collections:Department of Metabolism, Digestion and Reproduction
Department of Surgery and Cancer
Division of Cancer