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Inhibitory microcircuits for top-down plasticity of sensory representations

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Title: Inhibitory microcircuits for top-down plasticity of sensory representations
Authors: Wilmes, KA
Clopath, C
Item Type: Journal Article
Abstract: Rewards influence plasticity of early sensory representations. The underlying changes in cir-cuitry are however unclear. Recent experimental findings suggest that inhibitory circuits regu-late learning. In addition, inhibitory neurons are highly modulated by diverse long-range inputs,including reward signals. We, therefore, hypothesise that inhibitory plasticity plays a major rolein adjusting stimulus representations. We investigate how top-down modulation by rewards in-teracts with local plasticity to induce long-lasting changes in circuitry. Using a computationalmodel of layer 2/3 primary visual cortex, we demonstrate how interneuron circuits can storeinformation about rewarded stimuli to instruct long-term changes in excitatory connectivity inthe absence of further reward. In our model, stimulus-tuned somatostatin-positive interneuronsdevelop strong connections to parvalbumin-positive interneurons during reward such that theyselectively disinhibit the pyramidal layer henceforth. This triggers excitatory plasticity, leadingto increased stimulus representation. We make specific testable predictions and show that thistwo-stage model allows for translation invariance of the learned representation.
Issue Date: 7-Nov-2019
Date of Acceptance: 11-Oct-2019
URI: http://hdl.handle.net/10044/1/74517
DOI: 10.1038/s41467-019-12972-2
ISSN: 2041-1723
Publisher: Nature Research (part of Springer Nature)
Journal / Book Title: Nature Communications
Volume: 10
Copyright Statement: © 2019 The Author(s). This article is licensed under a Creative CommonsAttribution 4.0 International License, which permits use, sharing,adaptation, distribution and reproduction in any medium or format, as long as you giveappropriate credit to the original author(s) and the source, provide a link to the CreativeCommons license, and indicate if changes were made. The images or other third partymaterial in this article are included in the article’s Creative Commons license, unlessindicated otherwise in a credit line to the material. If material is not included in thearticle’s Creative Commons license and your intended use is not permitted by statutoryregulation or exceeds the permitted use, you will need to obtain permission directly fromthe copyright holder. To view a copy of this license, visithttp://creativecommons.org/licenses/by/4.0/
Sponsor/Funder: Wellcome Trust
Biotechnology and Biological Sciences Research Council (BBSRC)
Biotechnology and Biological Sciences Research Cou
Simons Foundation
National Institutes of Health
Funder's Grant Number: 200790/Z/16/Z
BB/P018785/1
ORCA 64155 (BB/N013956/1)
Award ID:564408
18-AO-00-1001392
Publication Status: Published
Article Number: ARTN 5055
Appears in Collections:Faculty of Engineering
Bioengineering



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