FOXK2 transcription factor and its emerging roles in cancer

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Title: FOXK2 transcription factor and its emerging roles in cancer
Authors: De Moraes, GN
Carneiro, LDT
Maia, RC
Lam, EW-F
Sharrocks, AD
Item Type: Journal Article
Abstract: Forkhead box (FOX) transcription factors compose a large family of regulators of key biological processes within a cell. FOXK2 is a member of FOX family, whose biological functions remain relatively unexplored, despite its description in the early nineties. More recently, growing evidence has been pointing towards a role of FOXK2 in cancer, which is likely to be context-dependent and tumour-specific. Here, we provide an overview of important aspects concerning the mechanisms of regulation of FOXK2 expression and function, as well as its complex interactions at the chromatin level, which orchestrate how it differentially regulates the expression of gene targets in pathophysiology. Particularly, we explore the emerging functions of FOXK2 as a regulator of a broad range of cancer features, such as cell proliferation and survival, DNA damage, metabolism, migration, invasion and metastasis. Finally, we discuss the prognostic value of assessing FOXK2 expression in cancer patients and how it can be potentially targeted for future anticancer interventions.
Issue Date: 20-Mar-2019
Date of Acceptance: 14-Mar-2019
URI: http://hdl.handle.net/10044/1/73243
DOI: https://doi.org/10.3390/cancers11030393
ISSN: 2072-6694
Publisher: MDPI AG
Journal / Book Title: Cancers
Volume: 11
Issue: 3
Copyright Statement: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
FOXK2 transcription factor
forkhead box
transcriptional activity
cancer
CELL-CYCLE
TUMOR-SUPPRESSOR
BINDING-FACTOR
FORKHEAD
PROTEINS
PROLIFERATION
BAP1
ACTIVATION
REPRESSION
EXPRESSION
FOXK2 transcription factor
cancer
forkhead box
transcriptional activity
Science & Technology
Life Sciences & Biomedicine
Oncology
FOXK2 transcription factor
forkhead box
transcriptional activity
cancer
CELL-CYCLE
TUMOR-SUPPRESSOR
BINDING-FACTOR
FORKHEAD
PROTEINS
PROLIFERATION
BAP1
ACTIVATION
REPRESSION
EXPRESSION
1112 Oncology and Carcinogenesis
Publication Status: Published
Article Number: ARTN 393
Online Publication Date: 2019-03-20
Appears in Collections:Division of Surgery
Division of Cancer



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