Entry of the bat influenza H17N10 virus into mammalian cells is enabled by the MHC class II HLA-DR receptor.

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Title: Entry of the bat influenza H17N10 virus into mammalian cells is enabled by the MHC class II HLA-DR receptor.
Authors: Giotis, ES
Carnell, G
Young, EF
Ghanny, S
Soteropoulos, P
Wang, L-F
Barclay, WS
Skinner, MA
Temperton, N
Item Type: Journal Article
Abstract: Haemagglutinin and neuraminidase surface glycoproteins of the bat influenza H17N10 virus neither bind to nor cleave sialic acid receptors, indicating that this virus employs cell entry mechanisms distinct from those of classical influenza A viruses. We observed that certain human haematopoietic cancer cell lines and canine MDCK II cells are susceptible to H17-pseudotyped viruses. We identified the human HLA-DR receptor as an entry mediator for H17 pseudotypes, suggesting that H17N10 possesses zoonotic potential.
Issue Date: 29-Jul-2019
Date of Acceptance: 20-Jun-2019
URI: http://hdl.handle.net/10044/1/73077
DOI: https://doi.org/10.1038/s41564-019-0517-3
ISSN: 2058-5276
Publisher: Nature Research
Journal / Book Title: Nature Microbiology
Copyright Statement: © 2019 Springer-Verlag. The final publication is available at Springer via https://doi.org/10.1038/s41564-019-0517-3
Publication Status: Published online
Conference Place: England
Embargo Date: 2020-01-29
Online Publication Date: 2019-07-29
Appears in Collections:Department of Medicine



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