Contrast vs non-contrast enhanced microvascular imaging using acoustic sub-aperture processing (ASAP): in vivo demonstration

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Title: Contrast vs non-contrast enhanced microvascular imaging using acoustic sub-aperture processing (ASAP): in vivo demonstration
Authors: Leow, CH
Braga, M
Bush, NL
Stanziola, A
Shah, A
Hernández-Gil, J
Long, NJ
Aboagye, EO
Bamber, JC
Tang, MX
Item Type: Conference Paper
Abstract: Angiogenesis plays a vital role in the progression of cancer. Non-invasive imaging techniques capable of assessing the microenvironment are therefore of clinical interest. Although highly sensitive vascular mapping has been demonstrated using ultrafast Power Doppler (PD), the detectability of microvasculature from the background noise may be hindered by the low signal-to-noise ratio (SNR) in deeper region and without the use of contrast agents. We recently developed acoustic sub-aperture processing (ASAP) processing for super-contrast vasculature imaging. This technique relies on the spatial coherence of the backscattered echoes over different acquisitions to substantially reduce the noise floor compared to the power Doppler (PD) technique. In this study, we demonstrate the feasibility of applying ASAP processing for non-contrast enhanced microvascular imaging in preclinical condition, and compare it with contrast enhanced ASAP as well as ultrafast PD. Comparing to PD, ASAP exhibit SNR improvement up to 12 dB. Higher SNR and extra visibility of smaller vessel are also demonstrated in contrast enhanced images in comparison to the non-contrast images. In conclusion, we have demonstrated the feasibility of using ASAP in vivo for non-contrast microvascular imaging, and the added benefit of using contrast agents in microvascular imaging.
Issue Date: 25-Feb-2019
Date of Acceptance: 22-Oct-2018
ISSN: 1948-5719
Publisher: IEEE
Journal / Book Title: IEEE International Ultrasonics Symposium, IUS
Copyright Statement: © 2018 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Sponsor/Funder: Cancer Research UK
Funder's Grant Number: 22353
Conference Name: IEEE International Ultrasonics Symposium, IUS. 2018
Publication Status: Published
Start Date: 2018-10-22
Finish Date: 2018-10-25
Conference Place: Kobe, Japan
Online Publication Date: 2019-02-25
Appears in Collections:Bioengineering
Division of Surgery
Catalysis and Advanced Materials
Division of Cancer
Faculty of Medicine
Faculty of Natural Sciences

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