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Development of Ga-68-labelled ultrasound microbubbles for whole-body PET imaging

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Title: Development of Ga-68-labelled ultrasound microbubbles for whole-body PET imaging
Authors: Hernandez-Gil, J
Braga, M
Harriss, B
Carroll, LS
Leow, CH
Tang, M-X
Aboagye, EO
Long, NJ
Item Type: Journal Article
Abstract: Microbubble (MB) contrast agents have revolutionalised the way ultrasound (US) imaging can be used clinically and pre-clinically. Contrast-enhanced US offers improvements in soft-tissue contrast, as well as the ability to visualise disease processes at the molecular level. However, its inability to provide in vivo whole-body imaging can hamper the development of new MB formulations. Herein, we describe a fast and efficient method for achieving 68Ga-labelling of MBs after a direct comparison of two different strategies. The optimised approach produces 68Ga-labelled MBs in good yields through the bioorthogonal inverse-electron-demand Diel–Alder reaction between a trans-cyclooctene-modified phospholipid and a new tetrazine-bearing HBED-CC chelator. The ability to noninvasively study the whole-body distribution of 68Ga-labelled MBs was demonstrated in vivo using positron emission tomography (PET). This method could be broadly applicable to other phospholipid-based formulations, providing accessible solutions for in vivo tracking of MBs.
Issue Date: 1-May-2019
Date of Acceptance: 18-Apr-2019
URI: http://hdl.handle.net/10044/1/72930
DOI: https://dx.doi.org/10.1039/c9sc00684b
ISSN: 2041-6520
Publisher: Royal Society of Chemistry
Start Page: 5603
End Page: 5615
Journal / Book Title: Chemical Science
Volume: 10
Issue: 21
Copyright Statement: © The Royal Society of Chemistry 2019. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence (https://creativecommons.org/licenses/by-nc/3.0/).
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
CONTRAST AGENTS
TUMOR ANGIOGENESIS
CLICK CHEMISTRY
HBED-CC
ANTIBODIES
CANCER
IMMUNOSCINTIGRAPHY
BIODISTRIBUTION
COMPLEXATION
STABILITIES
Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
CONTRAST AGENTS
TUMOR ANGIOGENESIS
CLICK CHEMISTRY
HBED-CC
ANTIBODIES
CANCER
IMMUNOSCINTIGRAPHY
BIODISTRIBUTION
COMPLEXATION
STABILITIES
Publication Status: Published
Online Publication Date: 2019-05-01
Appears in Collections:Bioengineering
Division of Surgery
Chemistry
Catalysis and Advanced Materials
Division of Cancer
Faculty of Medicine
Faculty of Natural Sciences



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