Common variants associated with plasma triglycerides and risk for coronary artery disease

Title: Common variants associated with plasma triglycerides and risk for coronary artery disease
Authors: Do, R
Willer, CJ
Schmidt, EM
Sengupta, S
Gao, C
Peloso, GM
Gustafsson, S
Kanoni, S
Ganna, A
Chen, J
Buchkovich, ML
Mora, S
Beckmann, JS
Bragg-Gresham, JL
Chang, H-Y
Demirkan, A
Den Hertog, HM
Donnelly, LA
Ehret, GB
Esko, T
Feitosa, MF
Ferreira, T
Fischer, K
Fontanillas, P
Fraser, RM
Freitag, DF
Gurdasani, D
Heikkila, K
Hyppoenen, E
Isaacs, A
Jackson, AU
Johansson, A
Johnson, T
Kaakinen, M
Kettunen, J
Kleber, ME
Li, X
Luan, J
Lyytikainen, L-P
Magnusson, PKE
Mangino, M
Mihailov, E
Montasser, ME
Mueller-Nurasyid, M
Nolte, IM
O'Connell, JR
Palmer, CD
Perola, M
Petersen, A-K
Sanna, S
Saxena, R
Service, SK
Shah, S
Shungin, D
Sidore, C
Song, C
Strawbridge, RJ
Surakka, I
Tanaka, T
Teslovich, TM
Thorleifsson, G
Van den Herik, EG
Voight, BF
Volcik, KA
Waite, LL
Wong, A
Wu, Y
Zhang, W
Absher, D
Asiki, G
Barroso, I
Been, LF
Bolton, JL
Bonnycastle, LL
Brambilla, P
Burnett, MS
Cesana, G
Dimitriou, M
Doney, ASF
Doering, A
Elliott, P
Epstein, SE
Eyjolfsson, GI
Gigante, B
Goodarzi, MO
Grallert, H
Gravito, ML
Groves, CJ
Hallmans, G
Hartikainen, A-L
Hayward, C
Hernandez, D
Hicks, AA
Holm, H
Hung, Y-J
Illig, T
Jones, MR
Kaleebu, P
Kastelein, JJP
Khaw, K-T
Kim, E
Klopp, N
Komulainen, P
Kumari, M
Langenberg, C
Lehtimaki, T
Lin, S-Y
Lindstrom, J
Loos, RJF
Mach, F
McArdle, WL
Meisinger, C
Mitchell, BD
Mueller, G
Nagaraja, R
Narisu, N
Nieminen, TVM
Nsubuga, RN
Olafsson, I
Ong, KK
Palotie, A
Papamarkou, T
Pomilla, C
Pouta, A
Rader, DJ
Reilly, MP
Ridker, PM
Rivadeneira, F
Rudan, I
Ruokonen, A
Samani, N
Scharnagl, H
Seeley, J
Silander, K
Stancakova, A
Stirrups, K
Swift, AJ
Tiret, L
Uitterlinden, AG
Van Pelt, LJ
Vedantam, S
Wainwright, N
Wijmenga, C
Wild, SH
Willemsen, G
Wilsgaard, T
Wilson, JF
Young, EH
Zhao, JH
Adair, LS
Arveiler, D
Assimes, TL
Bandinelli, S
Bennett, F
Bochud, M
Boehm, BO
Boomsma, DI
Borecki, IB
Bornstein, SR
Bovet, P
Burnier, M
Campbell, H
Chakravarti, A
Chambers, JC
Chen, Y-DI
Collins, FS
Cooper, RS
Danesh, J
Dedoussis, G
De Faire, U
Feranil, AB
Ferrieres, J
Ferrucci, L
Freimer, NB
Gieger, C
Groop, LC
Gudnason, V
Gyllensten, U
Hamsten, A
Harris, TB
Hingorani, A
Hirschhorn, JN
Hofman, A
Hovingh, GK
Hsiung, CA
Humphries, SE
Hunt, SC
Hveem, K
Iribarren, C
Jarvelin, M-R
Jula, A
Kahonen, M
Kaprio, J
Kesaniemi, A
Kivimaki, M
Kooner, JS
Koudstaal, PJ
Krauss, RM
Kuh, D
Kuusisto, J
Kyvik, KO
Laakso, M
Lakka, TA
Lind, L
Lindgren, CM
Martin, NG
Maerz, W
McCarthy, MI
McKenzie, CA
Meneton, P
Metspalu, A
Moilanen, L
Morris, AD
Munroe, PB
Njolstad, I
Pedersen, NL
Power, C
Pramstaller, PP
Price, JF
Psaty, BM
Quertermous, T
Rauramaa, R
Saleheen, D
Salomaa, V
Sanghera, DK
Saramies, J
Schwarz, PEH
Sheu, WH-H
Shuldiner, AR
Siegbahn, A
Spector, TD
Stefansson, K
Strachan, DP
Tayo, BO
Tremoli, E
Tuomilehto, J
Uusitupa, M
Van Duijn, CM
Vollenweider, P
Wallentin, L
Wareham, NJ
Whitfield, JB
Wolffenbuttel, BHR
Altshuler, D
Ordovas, JM
Boerwinkle, E
Palmer, CNA
Thorsteinsdottir, U
Chasman, DI
Rotter, JI
Franks, PW
Ripatti, S
Cupples, LA
Sandhu, MS
Rich, SS
Boehnke, M
Deloukas, P
Mohlke, KL
Ingelsson, E
Abecasis, GR
Daly, MJ
Neale, BM
Kathiresan, S
Item Type: Journal Article
Abstract: Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10−8 for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.
Issue Date: 1-Nov-2013
Date of Acceptance: 13-Sep-2013
URI: http://hdl.handle.net/10044/1/72543
DOI: https://doi.org/10.1038/ng.2795
ISSN: 1061-4036
Publisher: Nature Research
Start Page: 1345
End Page: 1352
Journal / Book Title: Nature Genetics
Volume: 45
Issue: 11
Copyright Statement: © 2013 Springer-Nature. The final publication is available at Springer via https://doi.org/10.1038/ng.2795
Keywords: Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
HIGH-DENSITY-LIPOPROTEIN
MENDELIAN RANDOMIZATION
HEART-DISEASE
CARDIOVASCULAR-DISEASE
GENETIC EPIDEMIOLOGY
CHOLESTEROL LEVELS
LOCI
CONTRIBUTE
THERAPY
Biological Transport
Cholesterol, HDL
Cholesterol, LDL
Coronary Artery Disease
Humans
Polymorphism, Single Nucleotide
Risk Factors
Triglycerides
Humans
Triglycerides
Risk Factors
Biological Transport
Polymorphism, Single Nucleotide
Cholesterol, LDL
Cholesterol, HDL
Coronary Artery Disease
Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
HIGH-DENSITY-LIPOPROTEIN
MENDELIAN RANDOMIZATION
HEART-DISEASE
CARDIOVASCULAR-DISEASE
GENETIC EPIDEMIOLOGY
CHOLESTEROL LEVELS
LOCI
CONTRIBUTE
THERAPY
Developmental Biology
11 Medical and Health Sciences
06 Biological Sciences
Publication Status: Published
Online Publication Date: 2013-10-06
Appears in Collections:National Heart and Lung Institute
Department of Medicine
Epidemiology, Public Health and Primary Care



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