Discovery and refinement of loci associated with lipid levels

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Title: Discovery and refinement of loci associated with lipid levels
Authors: Willer, CJ
Schmidt, EM
Sengupta, S
Peloso, GM
Gustafsson, S
Kanoni, S
Ganna, A
Chen, J
Buchkovich, ML
Mora, S
Beckmann, JS
Bragg-Gresham, JL
Chang, H-Y
Demirkan, A
Den Hertog, HM
Do, R
Donnelly, LA
Ehret, GB
Esko, T
Feitosa, MF
Ferreira, T
Fischer, K
Fontanillas, P
Fraser, RM
Freitag, DF
Gurdasani, D
Heikkila, K
Hyppoenen, E
Isaacs, A
Jackson, AU
Johansson, A
Johnson, T
Kaakinen, M
Kettunen, J
Kleber, ME
Li, X
Luan, J
Lyytikainen, L-P
Magnusson, PKE
Mangino, M
Mihailov, E
Montasser, ME
Mueller-Nurasyid, M
Nolte, IM
O'Connell, JR
Palmer, CD
Perola, M
Petersen, A-K
Sanna, S
Saxena, R
Service, SK
Shah, S
Shungin, D
Sidore, C
Song, C
Strawbridge, RJ
Surakka, I
Tanaka, T
Teslovich, TM
Thorleifsson, G
Van den Herik, EG
Voight, BF
Volcik, KA
Waite, LL
Wong, A
Wu, Y
Zhang, W
Absher, D
Asiki, G
Barroso, I
Been, LF
Bolton, JL
Bonnycastle, LL
Brambilla, P
Burnett, MS
Cesana, G
Dimitriou, M
Doney, ASF
Doering, A
Elliott, P
Epstein, SE
Eyjolfsson, GI
Gigante, B
Goodarzi, MO
Grallert, H
Gravito, ML
Groves, CJ
Hallmans, G
Hartikainen, A-L
Hayward, C
Hernandez, D
Hicks, AA
Holm, H
Hung, Y-J
Illig, T
Jones, MR
Kaleebu, P
Kastelein, JJP
Khaw, K-T
Kim, E
Klopp, N
Komulainen, P
Kumari, M
Langenberg, C
Lehtimaki, T
Lin, S-Y
Lindstrom, J
Loos, RJF
Mach, F
McArdle, WL
Meisinger, C
Mitchell, BD
Mueller, G
Nagaraja, R
Narisu, N
Nieminen, TVM
Nsubuga, RN
Olafsson, I
Ong, KK
Palotie, A
Papamarkou, T
Pomilla, C
Pouta, A
Rader, DJ
Reilly, MP
Ridker, PM
Rivadeneira, F
Rudan, I
Ruokonen, A
Samani, N
Scharnagl, H
Seeley, J
Silander, K
Stancakova, A
Stirrups, K
Swift, AJ
Tiret, L
Uitterlinden, AG
Van Pelt, LJ
Vedantam, S
Wainwright, N
Wijmenga, C
Wild, SH
Willemsen, G
Wilsgaard, T
Wilson, JF
Young, EH
Zhao, JH
Adair, LS
Arveiler, D
Assimes, TL
Bandinelli, S
Bennett, F
Bochud, M
Boehm, BO
Boomsma, DI
Borecki, IB
Bornstein, SR
Bovet, P
Burnier, M
Campbell, H
Chakravarti, A
Chambers, JC
Chen, Y-DI
Collins, FS
Cooper, RS
Danesh, J
Dedoussis, G
De Faire, U
Feranil, AB
Ferrieres, J
Ferrucci, L
Freimer, NB
Gieger, C
Groop, LC
Gudnason, V
Gyllensten, U
Hamsten, A
Harris, TB
Hingorani, A
Hirschhorn, JN
Hofman, A
Hovingh, GK
Hsiung, CA
Humphries, SE
Hunt, SC
Hveem, K
Iribarren, C
Jarvelin, M-R
Jula, A
Kahonen, M
Kaprio, J
Kesaniemi, A
Kivimaki, M
Kooner, JS
Koudstaal, PJ
Krauss, RM
Kuh, D
Kuusisto, J
Kyvik, KO
Laakso, M
Lakka, TA
Lind, L
Lindgren, CM
Martin, NG
Maerz, W
McCarthy, MI
McKenzie, CA
Meneton, P
Metspalu, A
Moilanen, L
Morris, AD
Munroe, PB
Njolstad, I
Pedersen, NL
Power, C
Pramstaller, PP
Price, JF
Psaty, BM
Quertermous, T
Rauramaa, R
Saleheen, D
Salomaa, V
Sanghera, DK
Saramies, J
Schwarz, PEH
Sheu, WH-H
Shuldiner, AR
Siegbahn, A
Spector, TD
Stefansson, K
Strachan, DP
Tayo, BO
Tremoli, E
Tuomilehto, J
Uusitupa, M
Van Duijn, CM
Vollenweider, P
Wallentin, L
Wareham, NJ
Whitfield, JB
Wolffenbuttel, BHR
Ordovas, JM
Boerwinkle, E
Palmer, CNA
Thorsteinsdottir, U
Chasman, DI
Rotter, JI
Franks, PW
Ripatti, S
Cupples, LA
Sandhu, MS
Rich, SS
Boehnke, M
Deloukas, P
Kathiresan, S
Mohlke, KL
Ingelsson, E
Abecasis, GR
Item Type: Journal Article
Abstract: Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10−8, including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.
Issue Date: 6-Oct-2013
Date of Acceptance: 13-Sep-2013
URI: http://hdl.handle.net/10044/1/72524
DOI: https://doi.org/10.1038/ng.2797
ISSN: 1061-4036
Publisher: Nature Research
Start Page: 1274
End Page: 1283
Journal / Book Title: Nature Genetics
Volume: 45
Issue: 11
Copyright Statement: © 2013, Springer Nature. The final publication is available at Springer via https://doi.org/10.1038/ng.2797
Sponsor/Funder: National Institute for Health Research
National Institute for Health Research
Funder's Grant Number: NF-SI-0611-10275
NF-SI-0611-10136
Keywords: Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
DENSITY-LIPOPROTEIN CHOLESTEROL
HEART-DISEASE
SUSCEPTIBILITY LOCI
IDENTIFIES 13
RISK
GENE
METAANALYSIS
HOMEOSTASIS
TRAITS
PLASMA
African Continental Ancestry Group
Asian Continental Ancestry Group
Cholesterol, HDL
Cholesterol, LDL
Coronary Artery Disease
European Continental Ancestry Group
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Lipids
Triglycerides
Global Lipids Genetics Consortium
Humans
Genetic Predisposition to Disease
Lipids
Triglycerides
Genotype
African Continental Ancestry Group
Asian Continental Ancestry Group
European Continental Ancestry Group
Cholesterol, LDL
Cholesterol, HDL
Coronary Artery Disease
Genome-Wide Association Study
Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
DENSITY-LIPOPROTEIN CHOLESTEROL
HEART-DISEASE
SUSCEPTIBILITY LOCI
IDENTIFIES 13
RISK
GENE
METAANALYSIS
HOMEOSTASIS
TRAITS
PLASMA
Developmental Biology
11 Medical and Health Sciences
06 Biological Sciences
Publication Status: Published
Online Publication Date: 2013-10-06
Appears in Collections:National Heart and Lung Institute
Department of Medicine
Epidemiology, Public Health and Primary Care



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