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Widespread microglial activation in multiple system atrophy

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Title: Widespread microglial activation in multiple system atrophy
Authors: Kübler, D
Wächter, T
Cabanel, N
Su, Z
Turkheimer, FE
Dodel, R
Brooks, DJ
Oertel, WH
Gerhard, A
Item Type: Journal Article
Abstract: Background The pattern and role of microglial activation in multiple system atrophy is largely unclear. The objective of this study was to use [11C](R)‐PK11195 PET to determine the extent and correlation of activated microglia with clinical parameters in MSA patients. Methods Fourteen patients with the parkinsonian phenotype of MSA (MSA‐P) with a mean disease duration of 2.9 years (range 2‐5 years) were examined with [11C](R)‐PK11195 PET and compared with 10 healthy controls. Results Patients with the parkinsonian phenotype of MSA showed a significant (P ≤ 0.01) mean increase in binding potentials compared with healthy controls in the caudate nucleus, putamen, pallidum, precentral gyrus, orbitofrontal cortex, presubgenual anterior cingulate cortex, and the superior parietal gyrus. No correlations between binding potentials and clinical parameters were found. Conclusions In early clinical stages of the parkinsonian phenotype of MSA, there is widespread microglial activation as a marker of neuroinflammatory changes without correlation to clinical parameters in our patient population. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
Issue Date: 1-Apr-2019
Date of Acceptance: 2-Jan-2019
URI: http://hdl.handle.net/10044/1/72429
DOI: https://dx.doi.org/10.1002/mds.27620
ISSN: 0885-3185
Publisher: Wiley
Start Page: 564
End Page: 568
Journal / Book Title: Movement Disorders
Volume: 34
Issue: 4
Copyright Statement: © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited (https://creativecommons.org/licenses/by/4.0/).
Keywords: Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences & Neurology
microglia
multiple system atrophy
neuroinflammation
PET
PK11195
DISEASE
BRAIN
BINDING
PET
PK11195
microglia
multiple system atrophy
neuroinflammation
Neurology & Neurosurgery
1103 Clinical Sciences
1106 Human Movement and Sports Sciences
1702 Cognitive Sciences
Publication Status: Published
Online Publication Date: 2019-02-06
Appears in Collections:Department of Medicine
Faculty of Medicine



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