Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Protocol for the 65 randomised clinical trial

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Title: Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Protocol for the 65 randomised clinical trial
Authors: Richards-Belle, A
Mouncey, P
Grieve, R
Harrison, D
Sadique, Z
Henry, D
Whitman, C
Camsooksai, J
Gordon, A
Young, D
Rowan, K
Lamontagne, F
Item Type: Journal Article
Abstract: The 65 trial is a pragmatic, multicentre, parallel-group, open-label, randomised clinical trial of permissive hypotension (targeting a mean arterial pressure target of 60–65 mmHg during vasopressor therapy) versus usual care in critically ill patients aged 65 years or over with vasodilatory hypotension. The trial will recruit 2600 patients from 65 United Kingdom adult general critical care units. The primary outcome is all-cause mortality at 90 days. An economic evaluation is embedded. This paper describes the proposed statistical and health economic analysis for the 65 trial.
Date of Acceptance: 20-May-2019
URI: http://hdl.handle.net/10044/1/72228
DOI: https://doi.org/10.1177/1751143719860387
ISSN: 1751-1437
Publisher: SAGE Publications (UK and US)
Start Page: 1
End Page: 11
Journal / Book Title: Journal of the Intensive Care Society
Copyright Statement: © The Intensive Care Society 2019 The final, definitive version of this paper has been published in Thomas, K., Patel, A., Sadique, M. Z., Grieve, R. D., Mason, A. J., Moler, S., … Harrison, D. A. (2019). Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Statistical and Health Economic Analysis Plan for the 65 trial. Journal of the Intensive Care Society by Sage Publications Ltd. All rights reserved. It is available at: https://doi.org/10.1177/1751143719860387
Publication Status: Published online
Online Publication Date: 2019-07-03
Appears in Collections:Division of Surgery



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