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New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

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Title: New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders
Authors: Evangelou, E
Gao, H
Blakeley, P
Pazoki, R
Suzuki, H
Elliott, J
Karaman, I
Jarvelin, MR
Tzoulaki, I
Bell, JD
Matthews, PM
Elliott, P
Item Type: Journal Article
Abstract: Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d−1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.
Issue Date: Sep-2019
Date of Acceptance: 11-Jun-2019
URI: http://hdl.handle.net/10044/1/72192
DOI: 10.1038/s41562-019-0653-z
ISSN: 2397-3374
Publisher: Nature Research
Start Page: 950
End Page: 961
Journal / Book Title: Nature Human Behaviour
Volume: 3
Issue: 9
Copyright Statement: © 2019 Springer Nature Publishing AG. The final publication is available at Springer via https://doi.org/10.1038/s41562-019-0653-z
Sponsor/Funder: Imperial College Healthcare NHS Trust- BRC Funding
Health Data Research Uk
National Institute for Health Research
Medical Research Council (MRC)
UK DRI Ltd
Funder's Grant Number: RDF03
Health Data Research UK
RTJ6219303-1
MR/L01341X/1
4050641385
Keywords: Social Sciences
Science & Technology
Life Sciences & Biomedicine
Psychology, Biological
Multidisciplinary Sciences
Neurosciences
Psychology, Experimental
Psychology
Science & Technology - Other Topics
Neurosciences & Neurology
GENOME-WIDE ASSOCIATION
HIGH-DENSITY-LIPOPROTEIN
PARKINSONS-DISEASE
CONSUMPTION
METAANALYSIS
VARIANTS
LOCI
EXPRESSION
RISK
DEPENDENCE
Publication Status: Published
Embargo Date: 2020-07-29
Online Publication Date: 2019-07-29
Appears in Collections:Department of Brain Sciences



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