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In vivo biocompatibility and immunogenicity of metal-phenolic gelation

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Title: In vivo biocompatibility and immunogenicity of metal-phenolic gelation
Authors: Björnmalm, M
Wong, LM
Wojciechowski, J
Penders, J
Horgan, C
Booth, M
Martin, N
Sattler, S
Stevens, M
Item Type: Working Paper
Abstract: In vivo forming hydrogels are of interest for diverse biomedical applications due to their ease-of-use and minimal invasiveness and therefore high translational potential. Supramolecular hydrogels that can be assembled using metal–phenolic coordination of naturally occurring polyphenols and group IV metal ions (e.g. Ti<sup>IV </sup>or Zr<sup>IV</sup>) provide a versatile and robust platform for engineering such materials. However, the in situ formation and in vivo response to this new class of materials has not yet been reported. Here, we demonstrate that metal–phenolic supramolecular gelation occurs successfully in vivo and we investigate the host response to the material over 14 weeks. The Ti<sup>IV</sup>–tannic acid materials form stable gels that are well-tolerated following subcutaneous injection. Histology reveals a mild foreign body reaction, and titanium biodistribution studies show low accumulation in distal tissues. Compared to poloxamer-based hydrogels (commonly used for in vivo gelation), Ti<sup>IV</sup>–tannic acid materials show substantially improved in vitro drug loading and release profile for the corticosteroid dexamethasone (from <1 day to >10 days). These results provide essential in vivo characterization for this new class of metal–phenolic hydrogels, and highlight their potential suitability for biomedical applications in areas such as drug delivery and regenerative medicine.<br>
Issue Date: 5-Jul-2019
URI: http://hdl.handle.net/10044/1/72151
DOI: https://dx.doi.org/10.26434/chemrxiv.8786048
Publisher: ChemRxiv
Copyright Statement: © 2019 Author(s).
Sponsor/Funder: European Commission
Funder's Grant Number: 745676
Publication Status: Published
Open Access location: https://doi.org/10.26434/chemrxiv.8786048.v1
Appears in Collections:Materials
National Heart and Lung Institute
Faculty of Medicine



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