Taming Brønsted acid reactivity: nucleophilic substitutions of propargylic alcohols with n-nucleophiles mediated by phosphorus-based Brønsted acid catalysts

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Title: Taming Brønsted acid reactivity: nucleophilic substitutions of propargylic alcohols with n-nucleophiles mediated by phosphorus-based Brønsted acid catalysts
Authors: Radtanajiravong, L
Diez-Gonzalez, S
Item Type: Journal Article
Abstract: The activity of diethyl phosphite and diphenyl phosphate in propargylation reactions with N-nucleophiles of varying basicity is presented. Careful choice of the reaction conditions minimised undesired rearrangements and arylation processes, typical side reactions with Brønsted acid catalysis. These systems are compatible with technical solvents and presence of air and they are also applicable to C-, O- and S-nucleophiles
Issue Date: 31-Jul-2019
Date of Acceptance: 14-Jun-2019
URI: http://hdl.handle.net/10044/1/71628
ISSN: 2470-1343
Publisher: American Chemical Society
Journal / Book Title: ACS Omega
Copyright Statement: This paper is embargoed until publication. Once published it will be available fully open access.
Publication Status: Accepted
Embargo Date: publication subject to indefinite embargo
Appears in Collections:Chemistry
Catalysis and Advanced Materials



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