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Genomic imprinting and its effects on postnatal growth and adult metabolism

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Title: Genomic imprinting and its effects on postnatal growth and adult metabolism
Authors: Millership, SJ
Van de Pette, M
Withers, DJ
Item Type: Journal Article
Abstract: Imprinted genes display parent-of-origin-specific expression with this epigenetic system of regulation found exclusively in therian mammals. Historically, defined imprinted gene functions were almost solely focused on pregnancy and the influence on the growth parameters of the developing embryo and placenta. More recently, a number of postnatal functions have been identified which converge on resource allocation, both for animals in the nest and in adults. While many of the prenatal functions of imprinted genes that have so far been described adhere to the "parental conflict" hypothesis, no clear picture has yet emerged on the functional role of imprints on postnatal metabolism. As these roles are uncovered, interest in the potential for these genes to influence postnatal metabolism and associated adult-onset disease outcomes when dysregulated has gathered pace. Here, we review the published data on imprinted genes and their influence on postnatal metabolism, starting in the nest, and then progressing through to adulthood. When observing the functional effects of these genes on adult metabolism, we must always be careful to acknowledge the influence both of direct expression in the relevant metabolic tissue, but also indirect metabolic programming effects caused by their modulation of both in utero and postnatal growth trajectories.
Issue Date: 3-Jul-2019
Date of Acceptance: 17-Jun-2019
URI: http://hdl.handle.net/10044/1/71627
DOI: https://dx.doi.org/10.1007/s00018-019-03197-z
ISSN: 1420-682X
Publisher: Springer (part of Springer Nature)
Journal / Book Title: Cellular and Molecular Life Sciences
Copyright Statement: © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Diet
Environment
Maternal care
Metabolic programming
Mouse models
Obesity
Diet
Environment
Maternal care
Metabolic programming
Mouse models
Obesity
0601 Biochemistry and Cell Biology
0606 Physiology
1103 Clinical Sciences
Biochemistry & Molecular Biology
Publication Status: Published online
Conference Place: Switzerland
Online Publication Date: 2019-07-03
Appears in Collections:Clinical Sciences
Molecular Sciences



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