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Renal clearable catalytic gold nanoclusters for in vivo disease monitoring

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Title: Renal clearable catalytic gold nanoclusters for in vivo disease monitoring
Authors: Loynachan, C
Soleimany, AP
Dudani, JS
Lin, Y
Najer, A
Bekdemir, A
Chen, Q
Bhatia, SN
Stevens, M
Item Type: Journal Article
Abstract: Ultra-small gold nanoclusters (AuNCs) have emerged as agile probes for in vivo imaging, as they exhibit exceptional tumour accumulation and efficient renal clearance properties. However, their intrinsic catalytic activity, which can enable increased detection sensitivity, has yet to be explored for in vivo sensing. By exploiting the peroxidase-mimicking activity of AuNCs and the precise nanometer size filtration of the kidney, we designed multifunctional protease nanosensors that respond to disease microenvironments to produce a direct colorimetric urinary readout of disease state in less than 1 h. We monitored the catalytic activity of AuNCs in collected urine of a mouse model of colorectal cancer where tumour-bearing mice showed a 13-fold increase in colorimetric signal compared to healthy mice. Nanosensors were eliminated completely through hepatic and renal excretion within 4 weeks after injection with no evidence of toxicity. We envision that this modular approach will enable rapid detection of a diverse range of diseases by exploiting their specific enzymatic signatures.
Issue Date: 2-Sep-2019
Date of Acceptance: 16-Jul-2019
URI: http://hdl.handle.net/10044/1/71621
DOI: 10.1038/s41565-019-0527-6
ISSN: 1748-3387
Publisher: Nature Research
Start Page: 883
End Page: 890
Journal / Book Title: Nature Nanotechnology
Volume: 14
Copyright Statement: © The Author(s), under exclusive licence to Springer Nature Limited 2019. The final publication is available at Springer via https://doi.org/10.1038/s41565-019-0527-6
Sponsor/Funder: Commission of the European Communities
Engineering & Physical Science Research Council (E
Wellcome Trust
Funder's Grant Number: ERC-2013-CoG-616417
EP/K031953/1
209121/Z/17/Z
Keywords: Science & Technology
Technology
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Science & Technology - Other Topics
Materials Science
METAL NANOCLUSTERS
NANOPARTICLES
BIOMARKERS
EFFICIENT
Nanoscience & Nanotechnology
Publication Status: Published
Embargo Date: 2020-03-02
Online Publication Date: 2019-09-02
Appears in Collections:Faculty of Engineering
Materials
Faculty of Natural Sciences



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