PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors

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Title: PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors
Authors: Merkenschlager, M
Von Boehmer, H
Item Type: Journal Article
Abstract: Expression of the regulatory T (T reg) cell–associated transcription factor Foxp3 can be induced by signals from the T cell receptor (TCR), interleukin-2 (IL-2), and transforming growth factor (TGF)-β. These signals are integrated by a network involving phosphatidylinositol 3 kinase (PI3K), protein kinase B (PKB; here referred to as Akt), and the mammalian target of rapamycin (mTOR). New studies show that the Foxo proteins Foxo1 and Foxo3a, which are inactivated by Akt, drive Foxp3 expression. These studies therefore explain the negative regulation of Foxp3 by PI3K signaling, and add Foxo proteins to the growing list of nuclear factors capable of modulating Foxp3 expression.
Issue Date: 5-Jul-2010
Date of Acceptance: 1-Jul-2010
URI: http://hdl.handle.net/10044/1/71589
DOI: https://doi.org/10.1084/jem.20101156
ISSN: 0022-1007
Publisher: Rockefeller University Press
Start Page: 1347
End Page: 1350
Journal / Book Title: Journal of Experimental Medicine
Volume: 207
Issue: 7
Copyright Statement: © 2010 Merkenschlager and von Boehmer This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
Sponsor/Funder: Medical Research Council (MRC)
Funder's Grant Number: PO4050659629
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
Medicine, Research & Experimental
Research & Experimental Medicine
REGULATORY T-CELLS
TRANSCRIPTION FACTOR FOXP3
RETINOIC-ACID
DNA METHYLATION
GENE-EXPRESSION
REG-CELLS
IN-VIVO
DIFFERENTIATION
RECEPTOR
MTOR
Animals
Conserved Sequence
Forkhead Transcription Factors
Humans
Intracellular Signaling Peptides and Proteins
Models, Biological
Phosphatidylinositol 3-Kinases
Protein-Serine-Threonine Kinases
Proto-Oncogene Proteins c-akt
Signal Transduction
TOR Serine-Threonine Kinases
Animals
Humans
Protein-Serine-Threonine Kinases
Intracellular Signaling Peptides and Proteins
Signal Transduction
Conserved Sequence
Models, Biological
Proto-Oncogene Proteins c-akt
Forkhead Transcription Factors
Phosphatidylinositol 3-Kinases
TOR Serine-Threonine Kinases
Science & Technology
Life Sciences & Biomedicine
Immunology
Medicine, Research & Experimental
Research & Experimental Medicine
REGULATORY T-CELLS
TRANSCRIPTION FACTOR FOXP3
RETINOIC-ACID
DNA METHYLATION
GENE-EXPRESSION
REG-CELLS
IN-VIVO
DIFFERENTIATION
RECEPTOR
MTOR
11 Medical and Health Sciences
Immunology
Publication Status: Published
Online Publication Date: 2010-07-05
Appears in Collections:Clinical Sciences
Molecular Sciences



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