Modulation of host cell processes by T3SS effectors

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Title: Modulation of host cell processes by T3SS effectors
Authors: Shenoy, AR
Furniss, RCD
Goddard, PJ
Clements, A
Item Type: Chapter
Abstract: Two of the enteric Escherichia coli pathotypes-enteropathogenic E. coli (EPEC) and enterohaemorrhagic E. coli (EHEC)-have a conserved type 3 secretion system which is essential for virulence. The T3SS is used to translocate between 25 and 50 bacterial proteins directly into the host cytosol where they manipulate a variety of host cell processes to establish a successful infection. In this chapter, we discuss effectors from EPEC/EHEC in the context of the host proteins and processes that they target-the actin cytoskeleton, small guanosine triphosphatases and innate immune signalling pathways that regulate inflammation and cell death. Many of these translocated proteins have been extensively characterised, which has helped obtain insights into the mechanisms of pathogenesis of these bacteria and also understand the host pathways they target in more detail. With increasing knowledge of the positive and negative regulation of host signalling pathways by different effectors, a future challenge is to investigate how the specific effector repertoire of each strain cooperates over the course of an infection.
Editors: Frankel, G
Ron, EZ
Issue Date: 30-Aug-2018
URI: http://hdl.handle.net/10044/1/71551
DOI: https://doi.org/10.1007/82_2018_106
Publisher: Springer Verlag
Journal / Book Title: Escherichia coli, a Versatile Pathogen
Copyright Statement: © Springer International Publishing AG, part of Springer Nature 2018. The final publication is available at Springer via https://doi.org/10.1007/82_2018_106
Sponsor/Funder: Medical Research Council (MRC)
Funder's Grant Number: MR/P028225/1
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
Microbiology
ENTEROPATHOGENIC ESCHERICHIA-COLI
NF-KAPPA-B
ACTIN PEDESTAL FORMATION
INNATE IMMUNE DETECTION
III SECRETED EFFECTOR
CITROBACTER-RODENTIUM
BACTERIAL EFFECTOR
NLRP3 INFLAMMASOME
SIGNALING PATHWAYS
SMALL GTPASES
Actin Cytoskeleton
Enteropathogenic Escherichia coli
Escherichia coli Infections
Escherichia coli Proteins
GTP Phosphohydrolases
Host-Pathogen Interactions
Humans
Immunity, Innate
Type III Secretion Systems
Humans
Escherichia coli Infections
GTP Phosphohydrolases
Escherichia coli Proteins
Enteropathogenic Escherichia coli
Host-Pathogen Interactions
Immunity, Innate
Actin Cytoskeleton
Type III Secretion Systems
0605 Microbiology
1107 Immunology
1108 Medical Microbiology
Immunology
Publication Status: Published online
Embargo Date: 2020-08-30
Article Number: 4
Online Publication Date: 2018-08-30
Appears in Collections:Department of Medicine
Faculty of Medicine
Faculty of Natural Sciences



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