Lipoprotein markers associated with disability from multiple sclerosis

File Description SizeFormat 
Lipoprotein markers associated with disability from multiple sclerosis.pdfPublished version1.49 MBAdobe PDFView/Open
Title: Lipoprotein markers associated with disability from multiple sclerosis
Authors: Gafson, AR
Thorne, T
McKechnie, CIJ
Jimenez, B
Nicholas, R
Matthews, PM
Item Type: Journal Article
Abstract: Altered lipid metabolism is a feature of chronic infammatory disorders. Increased plasma lipids and lipoproteins have been associated with multiple sclerosis (MS) disease activity. Our objective was to characterise the specifc lipids and associated plasma lipoproteins increased in MS and to test for an association with disability. Plasma samples were collected from 27 RRMS patients (median EDSS, 1.5, range 1–7) and 31 healthy controls. Concentrations of lipids within lipoprotein sub-classes were determined from NMR spectra. Plasma cytokines were measured using the MesoScale Discovery V-PLEX kit. Associations were tested using multivariate linear regression. Diferences between the patient and volunteer groups were found for lipids within VLDL and HDL lipoprotein sub-fractions (p<0.05). Multivariate regression demonstrated a high correlation between lipids within VLDL sub-classes and the Expanded Disability Status Scale (EDSS) (p<0.05). An optimal model for EDSS included free cholesterol carried by VLDL-2, gender and age (R2=0.38, p<0.05). Free cholesterol carried by VLDL-2 was highly correlated with plasma cytokines CCL-17 and IL-7 (R2=0.78, p<0.0001). These results highlight relationships between disability, infammatory responses and systemic lipid metabolism in RRMS. Altered lipid metabolism with systemic infammation may contribute to immune activation.
Issue Date: 16-Nov-2018
Date of Acceptance: 18-Oct-2018
URI: http://hdl.handle.net/10044/1/71506
DOI: https://doi.org/10.1038/s41598-018-35232-7
ISSN: 2045-2322
Publisher: Nature Publishing Group
Journal / Book Title: Scientific Reports
Volume: 8
Issue: 1
Copyright Statement: © 2018 The Authors. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
LOW-DENSITY-LIPOPROTEIN
J774 MACROPHAGES
CHOLESTEROL
PROGRESSION
ACCUMULATION
ATORVASTATIN
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
LOW-DENSITY-LIPOPROTEIN
J774 MACROPHAGES
CHOLESTEROL
PROGRESSION
ACCUMULATION
ATORVASTATIN
Publication Status: Published
Article Number: 17026
Online Publication Date: 2018-11-19
Appears in Collections:Division of Surgery
Department of Medicine
Faculty of Medicine



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Creative Commonsx