Does gender affect the prognosis and risk of complications in patients with congenital heart disease in the modern era?

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Title: Does gender affect the prognosis and risk of complications in patients with congenital heart disease in the modern era?
Authors: D'Alto, M
Budts, W
Diller, GP
Mulder, B
Egidy Assenza, G
Oreto, L
Ciliberti, P
Bassareo, PP
Gatzoulis, MA
Dimopoulos, K
Item Type: Journal Article
Abstract: Gender differences in the outcome of acquired cardiovascular disease are well known, but available literature on the influence of gender in congenital heart disease (CHD) is limited. Registries have provided valuable, albeit at times conflicting data. Higher mortality rates have been reported in older males with CHD, while sudden cardiac death is more prevalent in young males. However, mortality around surgery for CHD is higher in girls compared to boys, likely due to smaller body size. Women are at higher risk of developing pulmonary arterial hypertension, but at lower risk of adverse aortic outcomes, even though they are less likely to receive aortic surgery. Finally, women have a lower risk of presenting with infective endocarditis compared to men. The underlying reasons for gender differences in CHD can be attributed to genetic, hormonal, behavioural and other causes. The aim of the present paper is to provide an overview of available evidence on gender differences in CHD and their impact on outcome.
Issue Date: 1-Sep-2019
Date of Acceptance: 3-May-2019
ISSN: 0167-5273
Publisher: Elsevier
Start Page: 156
End Page: 161
Journal / Book Title: International Journal of Cardiology
Volume: 290
Copyright Statement: © 2019 Elsevier B.V. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence
Keywords: Congenital heart disease
Gender difference
Congenital heart disease
Gender difference
1102 Cardiorespiratory Medicine and Haematology
Cardiovascular System & Hematology
Publication Status: Published
Conference Place: Netherlands
Embargo Date: 2020-05-04
Online Publication Date: 2019-05-04
Appears in Collections:National Heart and Lung Institute

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