Non-alcoholic fatty liver disease and vascular disease

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Title: Non-alcoholic fatty liver disease and vascular disease
Authors: Forlano, R
Mullish, BH
Nathwani, R
Dhar, A
Thursz, MR
Manousou, P
Item Type: Journal Article
Abstract: Non-Alcoholic Fatty Liver Disease (NAFLD) represents an increasing cause of liver disease worldwide. However, notably, the primary cause of morbidity and mortality in patients with NAFLD is cardiovascular disease (CVD), with fibrosis stage being the strongest disease-specific predictor. It is globally-projected that NAFLD will become increasingly prevalent, especially among children and younger adults. As such, even within the next few years, NAFLD will contribute considerably to the overall CVD burden. In this review, we discuss the role of NAFLD as an emerging risk factor for CVD. In particular, this article aims to provide an overview of pathological drivers of vascular damage in patients with NAFLD. Moreover, the impact of NAFLD on the development, severity and the progression of subclinical and clinical CVD will be discussed. Finally, the review illustrates current and potential future perspectives for screening for CVD in this high-risk population.
Date of Acceptance: 7-Jun-2019
URI: http://hdl.handle.net/10044/1/70959
ISSN: 1570-1611
Publisher: Bentham Science Publishers
Journal / Book Title: Current Vascular Pharmacology
Copyright Statement: This paper is embargoed until 12 months after publication.
Sponsor/Funder: Medical Research Council
Medical Research Council (MRC)
Funder's Grant Number: MR/R00875/1
MR/R000875/1
Keywords: Cardiovascular System & Hematology
1115 Pharmacology and Pharmaceutical Sciences
Publication Status: Accepted
Embargo Date: Embargoed for 12 months after publication date
Appears in Collections:Division of Surgery
Faculty of Medicine



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