Gene-diet quality interactions on HbA1c and type 2 diabetes risk: The Airwave Health Monitoring Study

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Title: Gene-diet quality interactions on HbA1c and type 2 diabetes risk: The Airwave Health Monitoring Study
Authors: Eriksen, R
Gibson, R
Aresu, M
Heard, A
Chan, Q
Evangelou, E
Gao, H
Elliott, P
Frost, G
Item Type: Journal Article
Abstract: Introduction: Type 2 Diabetes (T2D) is multi-factorial involving lifestyle, environmental and genetic risk factors. This study aims to investigate the impact of genetic interactions with alcohol and diet quality on glycated haemoglobin A1c (HbA1c) independent of obesity, in a British population. Methods: Cross-sectional study of 14,089 white British participants from Airwave Health Monitoring Study, and a sub-sample of 3,733 participants with dietary data. A T2D genetic risk score (GRS) was constructed and its interactions with diet on HbA1c were assessed. Results: GRS was associated with a higher HbA1c% ( 0.03, p<0.0001) and a higher risk of pre-diabetes (OR 1.09, p<0.0001) and T2D (OR 1.14, p 0.006). The genetic effect on HbA1c% was significantly higher in obese participants ( 1.88, pinteraction 0.03). A high intake of wholegrain attenuated the effect on HbA1c% in high-risk individuals pinteraction 0.04. Conclusion: The genetic effect on HbA1c was almost doubled in obese individuals, compared with those with a healthy weight, and independent of weight there was a modest offset on HbA1c in high-genetic risk individuals consuming a diet high in wholegrain. This supports the importance of a healthy diet high in wholegrains and along with maintaining a healthy weight in controlling HbA1c amongst high genetic risk groups.
Issue Date: 11-Jul-2019
Date of Acceptance: 29-May-2019
URI: http://hdl.handle.net/10044/1/70702
DOI: https://dx.doi.org/10.1002/edm2.74
ISSN: 2398-9238
Publisher: Wiley
Journal / Book Title: Endocrinology, Diabetes & Metabolism
Copyright Statement: © 2019 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Sponsor/Funder: Home Office
Imperial College Healthcare NHS Trust- BRC Funding
Medical Research Council (MRC)
Medical Research Council (MRC)
Medical Research Council (MRC)
Funder's Grant Number: PG0484
RDF03
MR/L01341X/1
MR/L01632X/1
MR/L01632X/1
Publication Status: Published online
Article Number: e00074
Online Publication Date: 2019-07-11
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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