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Polyfunctionalised nanoparticles bearing robust gadolinium surface units for high relaxivity performance in MRI

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Title: Polyfunctionalised nanoparticles bearing robust gadolinium surface units for high relaxivity performance in MRI
Authors: Chabloz, N
Wenzel, M
Perry, H
Yoon, I
Molisso, S
Stasiuk, G
Elson, D
Cass, A
Wilton-Ely, J
Item Type: Journal Article
Abstract: The first example of an octadentate gadolinium unit based on DO3A (hydration number q = 1) with a dithiocarbamate tether has been designed and attached to the surface of gold nanoparticles (around 4.4 nm in diameter). In addition to the superior robustness of this attachment, the restricted rotation of the Gd complex on the nanoparticle surface leads to a dramatic increase in relaxivity (r1) from 4.0 mM‐1 s‐1 in unbound form to 34.3 mM‐1 s‐1 (at 10 MHz, 37 °C) and 22 ± 2 mM‐1s‐1 (at 63.87 MHz, 25 °C) when immobilised on the surface. The ‘one‐pot’ synthetic route provides a straightforward and versatile way of preparing a range of multifunctional gold nanoparticles. The incorporation of additional surface units improving biocompatibility (PEG and thioglucose units) and targeting (folic acid) lead to little detrimental effect on the high relaxivity observed for these non‐toxic multifunctional materials. In addition to the passive targeting attributed to gold nanoparticles, the inclusion of a unit capable of targeting the folate receptors overexpressed by cancer cells, such as HeLa cells, illustrates the potential of these assemblies.
Issue Date: 14-Aug-2019
Date of Acceptance: 22-May-2019
URI: http://hdl.handle.net/10044/1/70676
DOI: 10.1002/chem.201901820
ISSN: 0947-6539
Publisher: Wiley
Start Page: 10895
End Page: 10906
Journal / Book Title: Chemistry - A European Journal
Volume: 25
Issue: 46
Copyright Statement: © 2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is the accepted version of the following article: N. G. Chabloz, M. N. Wenzel, H. L. Perry, I.-C. Yoon, S. Molisso, G. J. Stasiuk, D. S. Elson, A. E. G. Cass, J. D. E. T. Wilton-Ely, Chem. Eur. J. 2019, 25, 10895, which has been published in final form at https://doi.org/10.1002/chem.201901820
Sponsor/Funder: Imperial College/Wellcome Trust Facility Network of Excellence scheme
Funder's Grant Number: P52862
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
dithiocarbamates
gadolinium
gold nanoparticles
imaging
MRI
FUNCTIONALIZED GOLD NANOPARTICLES
RESONANCE-IMAGING CONTRAST
FOLATE RECEPTOR
MULTIMETALLIC COMPLEXES
DITHIOCARBAMATE LIGANDS
SILICA NANOPARTICLES
PHOTOTHERMAL THERAPY
STEPWISE GENERATION
QUANTUM DOTS
AGENTS
MRI
dithiocarbamates
gadolinium
gold nanoparticles
imaging
General Chemistry
03 Chemical Sciences
Publication Status: Published online
Embargo Date: 2020-05-24
Online Publication Date: 2019-05-24
Appears in Collections:Division of Surgery
Chemistry
Biological and Biophysical Chemistry
Catalysis and Advanced Materials
Faculty of Medicine
Faculty of Natural Sciences



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