Characterisation of tumour microvessel density during progression of high-grade serous ovarian cancer: clinico-pathological impact (an OCTIPS Consortium study)

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Title: Characterisation of tumour microvessel density during progression of high-grade serous ovarian cancer: clinico-pathological impact (an OCTIPS Consortium study)
Authors: Ruscito, I
Castillo-Tong, DC
Vergote, I
Ignat, I
Stanske, M
Vanderstichele, A
Glajzer, J
Kulbe, H
Trillsch, F
Mustea, A
Kreuzinger, C
Panici, PB
Gourley, C
Gabra, H
Nuti, M
Taube, ET
Kessler, M
Sehouli, J
Darb-Esfahani, S
Braicu, EI
Item Type: Journal Article
Abstract: Background High-grade serous ovarian cancer (HGSOC) intratumoural vasculature evolution remains unknown. The study investigated changes in tumour microvessel density (MVD) in a large cohort of paired primary and recurrent HGSOC tissue samples and its impact on patients’ clinico-pathological outcome. Methods A total of 222 primary (pOC) and recurrent (rOC) intra-patient paired HGSOC were assessed for immunohistochemical expression of angiogenesis-associated biomarkers (CD31, to evaluate MVD, and VEGF-A). Expression profiles were compared between pOCs and rOCs and correlated with patients' data. Results High intratumoural MVD and VEGF-A expression were observed in 75.7% (84/111) and 20.7% (23/111) pOCs, respectively. MVDhigh and VEGF(+) samples were detected in 51.4% (57/111) and 20.7% (23/111) rOCs, respectively. MVDhigh/VEGF(+) co-expression was found in 19.8% (22/111) and 8.1% (9/111) of pOCs and rOCs, respectively (p = 0.02). Pairwise analysis showed no significant change in MVD (p = 0.935) and VEGF-A (p = 0.121) levels from pOCs to rOCs. MVDhigh pOCs were associated with higher CD3(+) (p = 0.029) and CD8(+) (p = 0.013) intratumoural effector TILs, while VEGF(+) samples were most frequently encountered among BRCA-mutated tumours (p = 0.019). Multivariate analysis showed VEGF and MVD were not independent prognostic factors for OS. Conclusions HGSOC intratumoural vasculature did not undergo significant changes during disease progression. High concentration of CD31(+) vessels seems to promote recruitment of effector TILs. The study also provides preliminary evidence of the correlation between VEGF-positivity and BRCA status.
Issue Date: 1-Aug-2018
Date of Acceptance: 1-Jun-2018
URI: http://hdl.handle.net/10044/1/70613
DOI: https://doi.org/10.1038/s41416-018-0157-z
ISSN: 0007-0920
Publisher: Springer Nature
Start Page: 330
End Page: 338
Journal / Book Title: British Journal of Cancer
Volume: 119
Issue: 3
Copyright Statement: © 2018 Cancer Research UK. This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/).
Sponsor/Funder: Commission of the European Communities
Funder's Grant Number: 279113
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
EPITHELIAL OVARIAN
PROGNOSTIC-FACTOR
BRCA2 MUTATIONS
CHEMOTHERAPY
CARCINOMA
BEVACIZUMAB
SURVIVAL
CELLS
WOMEN
VEGF
Science & Technology
Life Sciences & Biomedicine
Oncology
EPITHELIAL OVARIAN
PROGNOSTIC-FACTOR
BRCA2 MUTATIONS
CHEMOTHERAPY
CARCINOMA
BEVACIZUMAB
SURVIVAL
CELLS
WOMEN
VEGF
1112 Oncology and Carcinogenesis
Oncology & Carcinogenesis
Publication Status: Published
Online Publication Date: 2018-06-29
Appears in Collections:Division of Surgery
Division of Cancer



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