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Activation of Aurora A kinase increases YAP stability via blockage of autophagy

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Title: Activation of Aurora A kinase increases YAP stability via blockage of autophagy
Authors: Wang, P
Gong, Y
Guo, T
Li, M
Fang, L
Yin, S
Kamran, M
Liu, Y
Xu, J
Xu, L
Peng, F
Xue, X
Yang, M
Hung, M-C
Lam, EW-F
Gu, C
Wang, C
Zhan, Q
Liu, Q
Item Type: Journal Article
Abstract: Transcription cofactor Yes-associated protein (YAP) plays an important role in cancer progression. Here, we found that Aurora A kinase expression was positively correlated with YAP in lung cancer. Aurora A depletion suppresses lung cancer cell colony formation, which could be reversed by YAP ectopic overexpression. In addition, activation of Aurora A increases YAP protein abundance through maintaining its protein stability. Consistently, the transcriptional activity of YAP is increased upon Aurora A activation. We further showed that shAURKA suppressed YAP expression in the absence of Lats1/2, indicating that Aurora A regulates YAP independently of Hippo pathway. Instead, Aurora A induced blockage of autophagy to up-regulate YAP expression. Collectively, our findings provide insights into regulatory mechanisms of YAP expression in lung cancer development.
Issue Date: 3-Jun-2019
Date of Acceptance: 13-May-2019
URI: http://hdl.handle.net/10044/1/70536
DOI: https://dx.doi.org/10.1038/s41419-019-1664-4
ISSN: 2041-4889
Publisher: Nature Publishing Group
Journal / Book Title: Cell Death and Disease
Volume: 10
Copyright Statement: © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Sponsor/Funder: Breast Cancer Now
Breast Cancer Now
Medical Research Council (MRC)
Cancer Research UK
Funder's Grant Number: 2012NovemberPhD016
2012MayPR070
MR/N012097/1
C37/A12011
Publication Status: Published
Article Number: ARTN 432
Appears in Collections:Division of Surgery
Division of Cancer



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