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Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia

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Title: Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia
Authors: Hockham, C
Gupta, S
Penman, B
Bhatt, S
Piel, F
Item Type: Journal Article
Abstract: Severe forms of α-thalassaemia, haemoglobin H disease and haemoglobin Bart’s hydrops fetalis, are an important public health concern in Southeast Asia. Yet information on the prevalence, genetic diversity and health burden of α-thalassaemia in the region remains limited. We compiled a geodatabase of α-thalassaemia prevalence and genetic diversity surveys and, using geostatistical modelling methods, generated the first continuous maps of α-thalassaemia mutations in Thailand and sub-national estimates of the number of newborns with severe forms in 2020. We also summarised the current evidence-base for α-thalassaemia prevalence and diversity for the region. We estimate that 3595 (95% credible interval 1,717–6,199) newborns will be born with severe α-thalassaemia in Thailand in 2020, which is considerably higher than previous estimates. Accurate, fine-scale epidemiological data are necessary to guide sustainable national and regional health policies for α-thalassaemia management. Our maps and newborn estimates are an important first step towards this aim.
Issue Date: 23-May-2019
Date of Acceptance: 1-May-2019
URI: http://hdl.handle.net/10044/1/70410
DOI: https://dx.doi.org/10.7554/eLife.40580
ISSN: 2050-084X
Publisher: eLife Sciences Publications Ltd
Journal / Book Title: eLife
Volume: 8
Copyright Statement: © 2019, Hockham et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Keywords: Science & Technology
Life Sciences & Biomedicine
Biology
Life Sciences & Biomedicine - Other Topics
HEMOGLOBIN-H DISEASE
GLOBAL EPIDEMIOLOGY
HYDROPS-FETALIS
FREQUENCY
VARIANTS
HEALTH
Thalassaemia
epidemiology
genetic diversity
global health
human
newborn prevalence
spatial distribution
Publication Status: Published
Article Number: e40580
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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