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Computed tomography porosity and spherical indentation for determining cortical bone millimetre-scale mechanical properties

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Title: Computed tomography porosity and spherical indentation for determining cortical bone millimetre-scale mechanical properties
Authors: Boughton, O
Ma, S
Cai, X
Yan, L
Peralta, L
Laugier, P
Marrow, J
Giuliani, F
Hansen, U
Abel, R
Grimal, Q
Cobb, J
Item Type: Journal Article
Abstract: The cortex of the femoral neck is a key structural element of the human body, yet there is not a reliable metric for predicting the mechanical properties of the bone in this critical region. This study explored the use of a range of non-destructive metrics to measure femoral neck cortical bone stiffness at the millimetre length scale. A range of testing methods and imaging techniques were assessed for their ability to measure or predict the mechanical properties of cortical bone samples obtained from the femoral neck of hip replacement patients. Techniques that can potentially be applied in vivo to measure bone stiffness, including computed tomography (CT), bulk wave ultrasound (BWUS) and indentation, were compared against in vitro techniques, including compression testing, density measurements and resonant ultrasound spectroscopy. Porosity, as measured by micro-CT, correlated with femoral neck cortical bone’s elastic modulus and ultimate compressive strength at the millimetre length scale. Large-tip spherical indentation also correlated with bone mechanical properties at this length scale but to a lesser extent. As the elastic mechanical properties of cortical bone correlated with porosity, we would recommend further development of technologies that can safely measure cortical porosity in vivo. Introduction
Issue Date: 15-May-2019
Date of Acceptance: 23-Apr-2019
URI: http://hdl.handle.net/10044/1/70276
DOI: https://dx.doi.org/10.1038/s41598-019-43686-6
ISSN: 2045-2322
Publisher: Nature Publishing Group
Journal / Book Title: Scientific Reports
Volume: 9
Copyright Statement: © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre-ative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per-mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Sponsor/Funder: Imperial College Healthcare NHS Trust- BRC Funding
National Institute for Health Research
Royal College Of Surgeons Of England
Royal College of Surgeons of England
Royal College of Surgeons of England
Funder's Grant Number: RDB04 79560
NIHR ACF
WSSU_P63898
Matching orthopaedic surgery to patients' individual bone mechanical properties
Norman Capener Travelling Fellowship
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
TRABECULAR BONE
ELASTIC PROPERTIES
MINERAL DENSITY
YOUNGS MODULUS
FEMORAL-NECK
HUMAN FEMUR
PRESS-FIT
STRENGTH
ULTRASOUND
FIXATION
Publication Status: Published
Article Number: ARTN 7416
Appears in Collections:Mechanical Engineering
Materials
Division of Surgery
Faculty of Medicine
Faculty of Natural Sciences



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