A diversity of interneurons and Hebbian plasticity facilitates rapid compressible learning in hippocampus

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Title: A diversity of interneurons and Hebbian plasticity facilitates rapid compressible learning in hippocampus
Authors: Wilten, N
Clopath, C
Item Type: Journal Article
Abstract: The hippocampus is able to rapidly learn incoming information, even if that information is only observedonce. Further, this information can be replayed in a compressed format in either forward or reverse modesduring Sharp Wave Ripples (SPW-Rs). We leveraged state-of-the-art techniques in training recurrent spikingnetworks to demonstrate how primarily interneuron networks can: 1) generate internal theta sequences tobind externally elicited spikes in the presence of inhibition from Medial Septum, 2) compress learned spikesequences in the form of a SPW-R when septal inhibition is removed, 3) generate and refine high-frequencyassemblies during SPW-R mediated compression, and 4) regulate the inter-ripple-interval timing betweenSPW-Rs in ripple clusters. From the fast timescale of neurons to the slow timescale of behaviours, interneuronnetworks serve as the scaffolding for one-shot learning by replaying, reversing, refining, and regulating spikesequences.
Issue Date: 31-Jul-2019
Date of Acceptance: 23-Apr-2019
URI: http://hdl.handle.net/10044/1/70274
ISSN: 1097-6256
Publisher: Nature Research
Journal / Book Title: Nature Neuroscience
Sponsor/Funder: Wellcome Trust
Biotechnology and Biological Sciences Research Council (BBSRC)
Biotechnology and Biological Sciences Research Cou
Simons Foundation
Funder's Grant Number: 200790/Z/16/Z
BB/P018785/1
ORCA 64155 (BB/N013956/1)
Award ID:564408
Keywords: 1109 Neurosciences
1702 Cognitive Sciences
Neurology & Neurosurgery
Publication Status: Accepted
Embargo Date: 2020-01-31
Appears in Collections:Bioengineering



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