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A diversity of interneurons and Hebbian plasticity facilitate rapid compressible learning in the hippocampus

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Title: A diversity of interneurons and Hebbian plasticity facilitate rapid compressible learning in the hippocampus
Authors: Nicola, W
Clopath, C
Item Type: Journal Article
Abstract: The hippocampus is able to rapidly learn incoming information, even if that information is only observedonce. Further, this information can be replayed in a compressed format in either forward or reverse modesduring Sharp Wave Ripples (SPW-Rs). We leveraged state-of-the-art techniques in training recurrent spikingnetworks to demonstrate how primarily interneuron networks can: 1) generate internal theta sequences tobind externally elicited spikes in the presence of inhibition from Medial Septum, 2) compress learned spikesequences in the form of a SPW-R when septal inhibition is removed, 3) generate and refine high-frequencyassemblies during SPW-R mediated compression, and 4) regulate the inter-ripple-interval timing betweenSPW-Rs in ripple clusters. From the fast timescale of neurons to the slow timescale of behaviours, interneuronnetworks serve as the scaffolding for one-shot learning by replaying, reversing, refining, and regulating spikesequences.
Issue Date: Jul-2019
Date of Acceptance: 23-Apr-2019
URI: http://hdl.handle.net/10044/1/70274
DOI: 10.1038/s41593-019-0415-2
ISSN: 1097-6256
Publisher: Nature Research
Start Page: 1168
End Page: 1181
Journal / Book Title: Nature Neuroscience
Volume: 22
Issue: 7
Copyright Statement: © The Author(s), under exclusive licence to Springer Nature America, Inc. 2019. For Nature Research's Terms of Reuse of archived manuscripts please see: https://www.nature.com/nature-research/editorial-policies/self-archiving-and-license-to-publish#terms-for-use.
Sponsor/Funder: Wellcome Trust
Biotechnology and Biological Sciences Research Council (BBSRC)
Biotechnology and Biological Sciences Research Cou
Simons Foundation
Funder's Grant Number: 200790/Z/16/Z
BB/P018785/1
ORCA 64155 (BB/N013956/1)
Award ID:564408
Keywords: Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
THETA-PHASE PRECESSION
GAMMA-OSCILLATIONS
PLACE CELLS
CONTAINING NEURONS
ENTORHINAL CORTEX
SPIKE SEQUENCES
MEDIAL SEPTUM
SLOW ACTIVITY
MEMORY
RAT
CA3 Region, Hippocampal
Computer Simulation
Interneurons
Learning
Memory
Neural Networks (Computer)
Neuronal Plasticity
Septal Nuclei
Time Factors
Septal Nuclei
Interneurons
Learning
Memory
Neuronal Plasticity
Neural Networks (Computer)
Time Factors
Computer Simulation
CA3 Region, Hippocampal
1109 Neurosciences
1702 Cognitive Sciences
1701 Psychology
Neurology & Neurosurgery
Publication Status: Published
Online Publication Date: 2019-06-24
Appears in Collections:Faculty of Engineering
Bioengineering



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