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Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition

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Title: Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition
Authors: Solans, M
Benavente, Y
Saez, M
Agudo, A
Jakszyn, P
Naudin, S
Hosnijeh, FS
Gunter, M
Huybrechts, I
Ferrari, P
Besson, C
Mahamat-Saleh, Y
Boutron-Ruault, M-C
Kühn, T
Kaaks, R
Boeing, H
Lasheras, C
Sánchez, M-J
Amiano, P
Chirlaque, MD
Ardanaz, E
Schmidt, JA
Vineis, P
Riboli, E
Trichopoulou, A
Karakatsani, A
Valanou, E
Masala, G
Agnoli, C
Tumino, R
Sacerdote, C
Mattiello, A
Skeie, G
Weiderpass, E
Jerkeman, M
Dias, JA
Späth, F
Nilsson, LM
Dahm, CC
Overvad, K
Petersen, KEN
Tjønneland, A
De Sanjose, S
Vermeulen, R
Nieters, A
Casabonne, D
Item Type: Journal Article
Abstract: INTRODUCTION: Chronic inflammation plays a critical role in lymphomagenesis and several dietary factors seem to be involved its regulation. The aim of the current study was to assess the association between the inflammatory potential of the diet and the risk of lymphoma and its subtypes in the European Investigation into Cancer and Nutrition (EPIC) study. METHODS: The analysis included 476,160 subjects with an average follow-up of 13.9 years, during which 3,136 lymphomas (135 Hodgkin lymphoma (HL), 2606 non-Hodgkin lymphoma (NHL) and 395 NOS) were identified. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated using 28 dietary components and their corresponding inflammatory weights. The association between the ISD and lymphoma risk was estimated by hazard ratios (HR) and 95% confidence intervals (CI) calculated by multivariable Cox regression models adjusted for potential confounders. RESULTS: The ISD was not associated with overall lymphoma risk. Among lymphoma subtypes, a positive association between the ISD and mature B-cell NHL (HR for a 1-SD increase: 1.07 (95% CI 1.01; 1.14), p trend = 0.03) was observed. No statistically significant association was found among other subtypes. However, albeit with smaller number of cases, a suggestive association was observed for HL (HR for a 1-SD increase = 1.22 (95% CI 0.94; 1.57), p trend 0.13). CONCLUSIONS: Our findings suggested that a high ISD score, reflecting a pro-inflammatory diet, was modestly positively associated with the risk of B-cell lymphoma subtypes. Further large prospective studies on low-grade inflammation induced by diet are warranted to confirm these findings.
Issue Date: 22-Mar-2019
Date of Acceptance: 11-Mar-2019
URI: http://hdl.handle.net/10044/1/70022
DOI: https://dx.doi.org/10.1007/s00394-019-01947-0
ISSN: 0044-264X
Publisher: Springer Verlag
Journal / Book Title: European Journal of Nutrition
Copyright Statement: © Springer-Verlag GmbH Germany, part of Springer Nature 2019. The final publication is available at Springer via https://link.springer.com/article/10.1007%2Fs00394-019-01947-0
Keywords: Chronic inflammation
Inflammatory score of the diet
Lymphoma
Nutrition
Prospective studies
Chronic inflammation
Inflammatory score of the diet
Lymphoma
Nutrition
Prospective studies
Nutrition & Dietetics
1111 Nutrition and Dietetics
Publication Status: Published online
Conference Place: Germany
Embargo Date: 2020-03-22
Online Publication Date: 2019-03-22
Appears in Collections:Epidemiology, Public Health and Primary Care



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