Rapid short-pulse (RaSP) sequences improve the distribution of drug delivery to the brain in vivo

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Title: Rapid short-pulse (RaSP) sequences improve the distribution of drug delivery to the brain in vivo
Authors: Morse, SV
Pouliopoulos, AN
Chan, T
Lin, J
Copping, M
Long, NJ
Choi, JJ
Item Type: Conference Paper
Abstract: Focused ultrasound and microbubbles have been shown to locally and noninvasively open the blood-brain barrier. Despite encouraging results in human patients, several performance and safety features, such as poor drug distribution, high drug accumulation along vessels and small sites of red blood cell extravasation, have been unavoidable. We have recently developed a new ultrasound sequence - rapid short-pulse (RaSP) sequence - designed to suppress these adverse features by promoting safer modes of cavitation activity throughout capillaries. In our RaSP sequences, low-pressure short ultrasonic pulses are emitted at kHz pulse repetition frequencies (PRF) and grouped into bursts. We have shown in vitro that RaSP sequences prolong microbubble lifetime and increase their mobility, enhancing the distribution of acoustic cavitation activity. Here we evaluate the ability of RaSP sequences to improve the in vivo performance and safety of ultrasound-mediated drug delivery to the brain.
Issue Date: 2-Nov-2017
Date of Acceptance: 1-Jul-2017
URI: http://hdl.handle.net/10044/1/69912
DOI: hpps://dx.doi.org/10.1109/ULTSYM.2017.8092158
ISBN: 9781538633830
ISSN: 1948-5719
Publisher: IEEE
Journal / Book Title: IEEE International Ultrasonics Symposium, IUS
Copyright Statement: © 2017 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Conference Name: IEEE UFFC
Publication Status: Published
Start Date: 2017-09-06
Finish Date: 2017-09-09
Conference Place: Washington, DC, USA
Appears in Collections:Faculty of Engineering
Bioengineering
Chemistry
Catalysis and Advanced Materials
Faculty of Natural Sciences



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