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Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

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Title: Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
Authors: Bentley, AR
Sung, YJ
Brown, MR
Winkler, TW
Kraja, AT
Ntalla, I
Schwander, K
Chasman, D
Lim, E
Deng, X
Guo, X
Liu, J
Lu, Y
Cheng, C-Y
Sim, X
Vojinovic, D
Huffman, JE
Musani, SK
Li, C
Feitosa, MF
Richard, MA
Noordam, R
Baker, J
Chen, G
Aschard, H
Bartz, TM
Ding, J
Dorajoo, R
Manning, AK
Rankinen, T
Smith, A
Tajuddin, SM
Zhao, W
Graff, M
Alver, M
Boissel, M
Chai, JF
Chen, X
Divers, J
Evangelou, E
Gao, C
Goel, A
Hagemeijer, Y
Harris, SE
Hartwig, FP
He, M
Horimoto, ARVR
Hsu, F-C
Hung, Y-J
Jackson, AU
Kasturiratne, A
Komulainen, P
Kuehnel, B
Leander, K
Lin, K-H
Luan, J
Lyytikainen, L-P
Matoba, N
Nolte, IM
Pietzner, M
Prins, B
Riaz, M
Robino, A
Said, MA
Schupf, N
Scott, RA
Sofer, T
Stancakova, A
Takeuchi, F
Tayo, BO
Van der Most, PJ
Varga, TV
Wang, T-D
Wang, Y
Ware, EB
Wen, W
Xiang, Y-B
Yanek, LR
Zhang, W
Zhao, JH
Adeyemo, A
Afaq, S
Amin, N
Amini, M
Arking, DE
Arzumanyan, Z
Aung, T
Ballantyne, C
Barr, RG
Bielak, LF
Boerwinkle, E
Bottinger, EP
Broeckel, U
Brown, M
Cade, BE
Campbell, A
Canouil, M
Charumathi, S
Chen, Y-DI
Christensen, K
Concas, MP
Connell, JM
De las Fuentes, L
De Silva, HJ
De Vries, PS
Doumatey, A
Duan, Q
Eaton, CB
Eppinga, RN
Faul, JD
Floyd, JS
Forouhi, NG
Forrester, T
Friedlander, Y
Gandin, I
Gao, H
Ghanbari, M
Gharib, SA
Gigante, B
Giulianini, F
Grabe, HJ
Gu, CC
Harris, TB
Heikkinen, S
Heng, C-K
Hirata, M
Hixson, JE
Ikram, MA
Jia, Y
Joehanes, R
Johnson, C
Jonas, JB
Justice, AE
Katsuya, T
Khor, CC
Kilpelainen, TO
Koh, W-P
Kolcic, I
Kooperberg, C
Krieger, JE
Kritchevsky, SB
Kubo, M
Kuusisto, J
Lakka, TA
Langefeld, CD
Langenberg, C
Launer, LJ
Lehne, B
Lewis, CE
Li, Y
Liang, J
Lin, S
Liu, C-T
Liu, J
Liu, K
Loh, M
Lohman, KK
Louie, T
Luzzi, A
Magi, R
Mahajan, A
Manichaikul, AW
McKenzie, CA
Meitinger, T
Metspalu, A
Milaneschi, Y
Milani, L
Mohlke, KL
Momozawa, Y
Morris, AP
Murray, AD
Nalls, MA
Nauck, M
Nelson, CP
North, KE
O'Connell, JR
Palmer, ND
Papanicolau, GJ
Pedersen, NL
Peters, A
Peyser, PA
Polasek, O
Poulter, N
Raitakari, OT
Reiner, AP
Renstrom, F
Rice, TK
Rich, SS
Robinson, JG
Rose, LM
Rosendaal, FR
Rudan, I
Schmidt, CO
Schreiner, PJ
Scott, WR
Sever, P
Shi, Y
Sidney, S
Sims, M
Smith, JA
Snieder, H
Starr, JM
Strauch, K
Stringham, HM
Tan, NYQ
Tang, H
Taylor, KD
Teo, YY
Tham, YC
Tiemeier, H
Turner, ST
Uitterlinden, AG
Van Heemst, D
Waldenberger, M
Wang, H
Wang, L
Wang, L
Wei, WB
Williams, CA
Wilson, G
Wojczynski, MK
Yao, J
Young, K
Yu, C
Yuan, J-M
Zhou, J
Zonderman, AB
Becker, DM
Boehnke, M
Bowden, DW
Chambers, JC
Cooper, RS
De Faire, U
Deary, IJ
Elliott, P
Esko, T
Farrall, M
Franks, PW
Freedman, B
Froguel, P
Gasparini, P
Gieger, C
Horta, BL
Juang, J-MJ
Kamatani, Y
Kammerer, CM
Kato, N
Kooner, JS
Laakso, M
Laurie, CC
Lee, I-T
Lehtimaki, T
Magnusson, PKE
Oldehinkel, AJ
Penninx, BWJH
Pereira, AC
Rauramaa, R
Redline, S
Samani, NJ
Scott, J
Shu, X-O
Van der Harst, P
Wagenknecht, LE
Wang, J-S
Wang, YX
Wareham, NJ
Watkins, H
Weir, DR
Wickremasinghe, AR
Wu, T
Zeggini, E
Zheng, W
Bouchard, C
Evans, MK
Gudnason, V
Kardia, SLR
Liu, Y
Psaty, BM
Ridker, PM
Van Dam, RM
Mook-Kanamori, DO
Fornage, M
Province, MA
Kelly, TN
Fox, ER
Hayward, C
Van Duijn, CM
Tai, ES
Wong, TY
Loos, RJF
Franceschini, N
Rotter, J
Zhu, X
Bierut, LJ
Gauderman, WJ
Rice, K
Munroe, PB
Morrison, AC
Rao, DC
Rotimi, CN
Cupples, LA
Item Type: Journal Article
Abstract: The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.
Issue Date: 1-Apr-2019
Date of Acceptance: 7-Feb-2019
URI: http://hdl.handle.net/10044/1/69827
DOI: https://dx.doi.org/10.1038/s41588-019-0378-y
ISSN: 1061-4036
Publisher: Nature Research
Start Page: 636
End Page: 648
Journal / Book Title: Nature Genetics
Volume: 51
Issue: 4
Copyright Statement: © 2019 Springer Nature Publishing AG
Sponsor/Funder: Home Office
Action on Hearing Loss
Imperial College Healthcare NHS Trust- BRC Funding
Medical Research Council (MRC)
Medical Research Council (MRC)
Medical Research Council (MRC)
Funder's Grant Number: PG0484
G51_Chambers
RDF03
MR/L01341X/1
MR/L01632X/1
MR/L01632X/1
Keywords: Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
ENVIRONMENT INTERACTION
GENOTYPE IMPUTATION
NICOTINE METABOLISM
RISK LOCI
METAANALYSIS
ARCHITECTURE
CHOLESTEROL
CIGARETTES
VARIANTS
SUSCEPTIBILITY
Adolescent
Adult
Aged
Aged, 80 and over
Female
Genome-Wide Association Study
Genotype
Humans
Life Style
Linkage Disequilibrium
Lipids
Male
Middle Aged
Smoking
Young Adult
COGENT-Kidney Consortium
EPIC-InterAct Consortium
Understanding Society Scientific Group
Lifelines Cohort
11 Medical and Health Sciences
06 Biological Sciences
Developmental Biology
Publication Status: Published
Embargo Date: 2019-09-29
Online Publication Date: 2019-03-29
Appears in Collections:Epidemiology, Public Health and Primary Care



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