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First trimester circulating MicroRNA biomarkers predictive of subsequent preterm delivery and cervical shortening

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Title: First trimester circulating MicroRNA biomarkers predictive of subsequent preterm delivery and cervical shortening
Authors: Cook, J
Bennett, P
Kim, SH
Teoh, TG
Sykes, L
Kindinger, L
Garrett, A
MacIntyre, D
Terzidou, V
Item Type: Journal Article
Abstract: Preterm birth (PTB) is the leading cause of infant death and disability worldwide. The onset of preterm uterine contractions is preceded by asymptomatic cervical remodelling and ripening, which can be seen on trans-vaginal ultrasound as cervical shortening. This study aimed to identify plasma miRNA biomarkers that predict preterm birth and/or cervical shortening. We collected serial plasma samples from pregnant women prospectively from 12 to 22 weeks gestation. The nCounter miRNA assay was used to identify differentially expressed miRNAs associated with spontaneous PTB and/or cervical shortening (n = 16 term no short, n = 13 preterm, n = 24 short). Predictive values of the miRNA biomarkers were confirmed in an independent validation cohort consisting of 96 women who delivered at term, 14 preterm and 21 early cervical shortening at <20 weeks gestation. Nine miRNAs (hsa-let-7a-5p, hsa-miR-374a-5p, hsa-miR-15b-5p, hsa-miR-19b-3p, hsa-miR-23a-3p, hsa-miR-93-5p, hsa-miR-150-5p, hsa-miR-185-5p and hsa-miR-191-5p) were differentially expressed (P < 0.001) in women subsequently experiencing PTB or cervical shortening. Hsa-miR-150-5p had the strongest ability to predict PTB (AUC = 0.8725) and cervical shortening (AUC = 0.8514). Plasma miRNAs in the first trimester can predict PTB and cervical shortening in women at risk of preterm delivery. This is a key period in pregnancy when early identification of PTB risk allows time to deliver outcome-modifying interventions.
Issue Date: 10-Apr-2019
Date of Acceptance: 22-Mar-2019
URI: http://hdl.handle.net/10044/1/69685
DOI: https://dx.doi.org/10.1038/s41598-019-42166-1
ISSN: 2045-2322
Publisher: Nature Publishing Group
Journal / Book Title: Scientific Reports
Volume: 9
Copyright Statement: © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre-ative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per-mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Sponsor/Funder: Medical Research Council (MRC)
Medical Research Council (MRC)
Imperial College Healthcare NHS Trust- BRC Funding
Action Medical Research
Seattle ChildrensHospital Research Foundation
Genesis Research Trust
Imperial College Healthcare NHS Trust- BRC Funding
Imperial College Healthcare NHS Trust- BRC Funding
Imperial College Healthcare NHS Trust- BRC Funding
Funder's Grant Number: MR/L009226/1
MR/L009226/1
RD502
GN2248
N/A
1811
RDC03
RDD03 79560
RDF01 79560
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
LENGTH
PREGNANCY
PROLIFERATION
EXPRESSION
BIRTH
RISK
Publication Status: Published
Article Number: ARTN 5861
Appears in Collections:Division of Surgery
Faculty of Medicine



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