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Assisting continuous biomanufacturing through advanced control in downstream purification

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Title: Assisting continuous biomanufacturing through advanced control in downstream purification
Authors: Papathanasiou, MM
Burnak, B
Katz, J
Shah, N
Pistikopoulos, EN
Item Type: Journal Article
Abstract: Aiming to significantly improve their processes and secure market share, monoclonal antibody (mAb) manufacturers seek innovative solutions that will yield improved production profiles. In that space, continuous manufacturing has been gaining increasing interest, promising more stable processes with lower operating costs. However, challenges in the operation and control of such processes arise mainly from the lack of appropriate process analytics tools that will provide the required measurements to guarantee product quality. Here we demonstrate a Process Systems Engineering approach for the design a novel control scheme for a semi-continuous purification process. The controllers are designed employing multi-parametric Model Predictive Control (mp-MPC) strategies and the successfully manage to: (a) follow the system periodicity, (b) respond to measured disturbances and (c) result in satisfactory yield and product purity. The proposed strategy is also compared to experimentally optimized profiles, yielding a satisfactory agreement.
Issue Date: 9-Jun-2019
Date of Acceptance: 7-Mar-2019
URI: http://hdl.handle.net/10044/1/69655
DOI: https://dx.doi.org/10.1016/j.compchemeng.2019.03.013
ISSN: 0098-1354
Publisher: Elsevier B.V.
Start Page: 232
End Page: 248
Journal / Book Title: Computers and Chemical Engineering
Volume: 125
Copyright Statement: © 2019 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: Engineering & Physical Science Research Council (E
Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: EP/P006485/1 - 000029212
EP/R013764/1
Keywords: 0904 Chemical Engineering
0913 Mechanical Engineering
Chemical Engineering
Publication Status: Published
Embargo Date: 2020-03-15
Online Publication Date: 2019-03-15
Appears in Collections:Centre for Environmental Policy
Chemical Engineering
Faculty of Natural Sciences



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