Soft robotic surrogate lung

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Title: Soft robotic surrogate lung
Authors: Ranunkel, O
Guder, F
Arora, H
Item Type: Journal Article
Abstract: Previous artificial lung surrogates used hydrogels or balloon-like inflatable structures without reproducing the alveolar network or breathing action within the lung. A physiologically accurate, air-filled lung model inspired by soft robotics is presented. The model, soft robotic surrogate lung (SRSL), is composed of clusters of artificial alveoli made of platinum-cured silicone, with internal pathways for air flow. Mechanical tests in conjunction with full-field image and volume correlation techniques characterize the SRSL behavior. SRSLs enable both healthy and pathological lungs to be studied in idealized cases. Although simple in construction, the connected airways demonstrate clearly the importance of an inflatable network for capturing basic lung behavior (compared to more simplified lung surrogates). The SRSL highlights the potentially damaging nature of local defects caused by occlusion or overdistension (present in conditions such as chronic obstructive pulmonary disease). The SRSL is developed as a potential upgrade to conventional surrogates used for injury risk predictions in trauma. The deformation of the SRSL is evaluated against blast trauma using a shock tube. The SRSL was compared to other conventional trauma surrogate materials and showed greatest similarity to lung tissue. The SRSL has the potential to complement conventional biomechanical studies and reduce animal use in basic biomechanics studies, where high severity protocols are used.
Issue Date: 15-Apr-2019
Date of Acceptance: 8-Mar-2019
URI: http://hdl.handle.net/10044/1/69583
DOI: htts://dx.doi.org/10.1021/acsabm.8b00753
ISSN: 2576-6422
Publisher: American Chemical Society
Start Page: 1490
End Page: 1497
Journal / Book Title: ACS Applied Bio Materials
Volume: 2
Issue: 4
Copyright Statement: © 2016 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Bio Materials, after peer review and technical editing by the publisher. To access the final edited and published work see htts://dx.doi.org/10.1021/acsabm.8b00753
Sponsor/Funder: AWE Plc
Funder's Grant Number: PO# 30381076/0
Publication Status: Published
Embargo Date: 2020-03-08
Article Number: acsabm.8b00753
Online Publication Date: 2019-03-08
Appears in Collections:Bioengineering



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