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Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam

Title: Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam
Authors: Phan, VTM
Rabaa, MA
Donato, C
Cowley, D
Voong, VP
Iran, TND
Pham, HA
Ha, V
Bryant, JE
Kellam, P
Thwaites, G
Woolhouse, MEJ
Kirkwood, CD
Baker, S
Item Type: Journal Article
Abstract: During a hospital-based diarrhoeal disease study conducted in Ho Chi Minh City, Vietnam from 2009 to 2010, we identified four symptomatic children infected with G26P[19] rotavirus (RV) – an atypical variant that has not previously been reported in human gastroenteritis. To determine the genetic structure and investigate the origin of this G26P[19] strain, the whole genome of a representative example was characterized, revealing a novel genome constellation: G26–P[19]–I5–R1–C1–M1–A8–N1–T1–E1–H1. The genome segments were most closely related to porcine (VP7, VP4, VP6 and NSP1) and Wa-like porcine RVs (VP1–3 and NSP2–5). We proposed that this G26P[19] strain was the product of zoonotic transmission coupled with one or more reassortment events occurring in human and/or animal reservoirs. The identification of such strains has potential implications for vaccine efficacy in south-east Asia, and outlines the utility of whole-genome sequencing for studying RV diversity and zoonotic potential during disease surveillance.
Issue Date: 1-Dec-2014
Date of Acceptance: 12-Aug-2014
URI: http://hdl.handle.net/10044/1/69581
DOI: https://dx.doi.org/10.1099/vir.0.068403-0
ISSN: 1465-2099
Publisher: Microbiology Society
Start Page: 2727
End Page: 2733
Journal / Book Title: Journal of General Virology
Volume: 95
Issue: 12
Copyright Statement: © 2014 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/).
Keywords: Science & Technology
Life Sciences & Biomedicine
Biotechnology & Applied Microbiology
Virology
GROUP-A ROTAVIRUSES
CLOSE RELATIONSHIP
SEQUENCE-ANALYSIS
GENOMIC ANALYSIS
VP4 GENES
STRAIN
GENOTYPE
CHILDREN
ORIGIN
PHYLOGENIES
Child, Preschool
Diarrhea
Genotype
Humans
Inpatients
Molecular Sequence Data
Phylogeny
Rotavirus
Rotavirus Infections
Vietnam
06 Biological Sciences
07 Agricultural and Veterinary Sciences
11 Medical and Health Sciences
Publication Status: Published
Online Publication Date: 2014-12-01
Appears in Collections:Department of Medicine



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