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Identification of a novel human rhinovirus C type by antibody capture VIDISCA-454

Title: Identification of a novel human rhinovirus C type by antibody capture VIDISCA-454
Authors: Farsani, SMJ
Munnink, BBO
Canuti, M
Deijs, M
Cotten, M
Jebbink, MF
Verhoeven, J
Kellam, P
Loens, K
Goossens, H
Ieven, M
Van der Hoek, L
Item Type: Journal Article
Abstract: Causative agents for more than 30 percent of respiratory infections remain unidentified, suggesting that unknown respiratory pathogens might be involved. In this study, antibody capture VIDISCA-454 (virus discovery cDNA-AFLP combined with Roche 454 high-throughput sequencing) resulted in the discovery of a novel type of rhinovirus C (RV-C). The virus has an RNA genome of at least 7054 nt and carries the characteristics of rhinovirus C species. The gene encoding viral protein 1, which is used for typing, has only 81% nucleotide sequence identity with the closest known RV-C type, and, therefore, the virus represents the first member of a novel type, named RV-C54.
Issue Date: 1-Jan-2015
Date of Acceptance: 1-Jan-2015
URI: http://hdl.handle.net/10044/1/69571
DOI: https://dx.doi.org/10.3390/v7010239
ISSN: 1999-4915
Publisher: MDPI AG
Start Page: 239
End Page: 251
Journal / Book Title: Viruses
Volume: 7
Issue: 1
Copyright Statement: © 2015 The Author(s). This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0 - https://creativecommons.org/licenses/by/4.0/).
Keywords: Science & Technology
Life Sciences & Biomedicine
Virology
rhinovirus C54
virus discovery
antibody capture VIDISCA-454
ACUTE RESPIRATORY-INFECTIONS
MULTIPLE SEQUENCE ALIGNMENT
EPITHELIAL-CELLS
PROPAGATION
GENETICS
VIRUSES
ILLNESS
MUSCLE
Adult
Antibodies, Viral
Cluster Analysis
Female
Genome, Viral
Humans
Molecular Sequence Data
Phylogeny
Picornaviridae Infections
RNA, Viral
Respiratory System
Respiratory Tract Infections
Rhinovirus
Sequence Analysis, DNA
Sequence Homology
Publication Status: Published
Online Publication Date: 2015-01-19
Appears in Collections:Department of Medicine



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