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Strategies for tackling Taenia solium taeniosis/cysticercosis: A systematic review and comparison of transmission models, including an assessment of the wider Taeniidae family transmission models

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Title: Strategies for tackling Taenia solium taeniosis/cysticercosis: A systematic review and comparison of transmission models, including an assessment of the wider Taeniidae family transmission models
Authors: Dixon, MA
Braae, UC
Winskill, P
Walker, M
Devleesschauwer, B
Gabriël, S
Basáñez, M-G
Item Type: Journal Article
Abstract: Background The cestode Taenia solium causes the neglected (zoonotic) tropical disease cysticercosis, a leading cause of preventable epilepsy in endemic low and middle-income countries. Transmission models can inform current scaling-up of control efforts by helping to identify, validate and optimise control and elimination strategies as proposed by the World Health Organization (WHO). Methodology/Principal findings A systematic literature search was conducted using the PRISMA approach to identify and compare existing T. solium transmission models, and related Taeniidae infection transmission models. In total, 28 modelling papers were identified, of which four modelled T. solium exclusively. Different modelling approaches for T. solium included deterministic, Reed-Frost, individual-based, decision-tree, and conceptual frameworks. Simulated interventions across models agreed on the importance of coverage for impactful effectiveness to be achieved. Other Taeniidae infection transmission models comprised force-of-infection (FoI), population-based (mainly Echinococcus granulosus) and individual-based (mainly E. multilocularis) modelling approaches. Spatial structure has also been incorporated (E. multilocularis and Taenia ovis) in recognition of spatial aggregation of parasite eggs in the environment and movement of wild animal host populations. Conclusions/Significance Gaps identified from examining the wider Taeniidae family models highlighted the potential role of FoI modelling to inform model parameterisation, as well as the need for spatial modelling and suitable structuring of interventions as key areas for future T. solium model development. We conclude that working with field partners to address data gaps and conducting cross-model validation with baseline and longitudinal data will be critical to building consensus-led and epidemiological setting-appropriate intervention strategies to help fulfil the WHO targets.
Issue Date: 10-Apr-2019
Date of Acceptance: 13-Mar-2019
URI: http://hdl.handle.net/10044/1/69500
DOI: https://dx.doi.org/10.1371/journal.pntd.0007301
ISSN: 1935-2727
Publisher: Public Library of Science
Journal / Book Title: PLoS Neglected Tropical Diseases
Volume: 13
Issue: 4
Copyright Statement: © 2019 Dixon et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sponsor/Funder: Medical Research Council
Funder's Grant Number: MR/K501281/1
Keywords: Animals
Animals, Wild
Cysticercosis
Disease Eradication
Humans
Infection Control
Models, Biological
Swine
Swine Diseases
Taenia solium
Taeniasis
World Health Organization
Zoonoses
06 Biological Sciences
11 Medical and Health Sciences
Tropical Medicine
Publication Status: Published
Article Number: e0007301
Appears in Collections:Faculty of Medicine
Epidemiology, Public Health and Primary Care



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