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AMP-activated protein kinase: the current landscape for drug development

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Title: AMP-activated protein kinase: the current landscape for drug development
Authors: Steinberg, GR
Carling, D
Item Type: Journal Article
Abstract: Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy homeostasis, many exciting insights into its structure, regulation and physiological roles have been revealed. While exercise, caloric restriction, metformin and many natural products increase AMPK activity and exert a multitude of health benefits, developing direct activators of AMPK to elicit beneficial effects has been challenging. However, in recent years, direct AMPK activators have been identified and tested in preclinical models, and a small number have entered clinical trials. Despite these advances, which disease(s) represent the best indications for therapeutic AMPK activation and the long-term safety of such approaches remain to be established.
Issue Date: 13-Mar-2019
Date of Acceptance: 1-Mar-2019
URI: http://hdl.handle.net/10044/1/69491
DOI: https://dx.doi.org/10.1038/s41573-019-0019-2
ISSN: 1474-1776
Publisher: Nature Research (part of Springer Nature)
Journal / Book Title: Nature Reviews Drug Discovery
Copyright Statement: © 2019 Springer Nature. The final publication is available at Springer via https://dx.doi.org/10.1038/s41573-019-0019-2
Keywords: 11 Medical and Health Sciences
06 Biological Sciences
Pharmacology & Pharmacy
Publication Status: Published online
Conference Place: England
Embargo Date: 2019-09-13
Online Publication Date: 2019-03-13
Appears in Collections:Clinical Sciences
Molecular Sciences



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