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Community case clusters of Middle East respiratory syndrome coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: A descriptive genomic study

Title: Community case clusters of Middle East respiratory syndrome coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: A descriptive genomic study
Authors: Memish, ZA
Cotten, M
Watson, SJ
Kellam, P
Zumla, A
Alhakeem, RF
Assiri, A
Al Rabeeah, AA
Al-Tawfiq, JA
Item Type: Journal Article
Abstract: The Middle East respiratory syndrome coronavirus (MERS-CoV) was first described in September 2012 and to date 86 deaths from a total of 206 cases of MERS-CoV infection have been reported to the WHO. Camels have been implicated as the reservoir of MERS-CoV, but the exact source and mode of transmission for most patients remain unknown. During a 3 month period, June to August 2013, there were 12 positive MERS-CoV cases reported from the Hafr Al-Batin region district in the north east region of the Kingdom of Saudi Arabia. In addition to the different regional camel festivals in neighboring countries, Hafr Al-Batin has the biggest camel market in the entire Kingdom and hosts an annual camel festival. Thus, we conducted a detailed epidemiological, clinical and genomic study to ascertain common exposure and transmission patterns of all cases of MERS-CoV reported from Hafr Al-Batin. Analysis of previously reported genetic data indicated that at least two of the infected contacts could not have been directly infected from the index patient and alternate source should be considered. While camels appear as the likely source, other sources have not been ruled out. More detailed case control studies with detailed case histories, epidemiological information and genomic analysis are being conducted to delineate the missing pieces in the transmission dynamics of MERS-CoV outbreak.
Issue Date: 1-Jun-2014
Date of Acceptance: 1-Mar-2014
URI: http://hdl.handle.net/10044/1/69467
DOI: https://dx.doi.org/10.1016/j.ijid.2014.03.1372
ISSN: 1201-9712
Publisher: Elsevier
Start Page: 63
End Page: 68
Journal / Book Title: International Journal of Infectious Diseases
Volume: 23
Copyright Statement: © 2014 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/)
Keywords: Science & Technology
Life Sciences & Biomedicine
Infectious Diseases
Middle East
Community
Clusters
MERS-CoV
Genome
Phylogeny
Coronavirus
Virus transmission
CLINICAL-FEATURES
DROMEDARY CAMELS
FAMILY CLUSTER
INFECTIONS
TRANSMISSION
Adolescent
Adult
Aged
Animals
Camelus
Child
Child, Preschool
Comorbidity
Contact Tracing
Coronavirus Infections
Female
Genome, Viral
Humans
Male
Middle Aged
Middle East Respiratory Syndrome Coronavirus
Saudi Arabia
Young Adult
0605 Microbiology
1108 Medical Microbiology
Microbiology
Publication Status: Published
Online Publication Date: 2014-03-31
Appears in Collections:Department of Medicine



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