Altmetric

Rheological characterization of biomaterials directs additive manufacturing of strontium-substituted bioactive Gglass/polycaprolactone microfibers

File Description SizeFormat 
Paxton_wt al accepted.pdfFile embargoed until 01 April 2020750.5 kBAdobe PDF    Request a copy
Title: Rheological characterization of biomaterials directs additive manufacturing of strontium-substituted bioactive Gglass/polycaprolactone microfibers
Authors: Paxton, NC
Ren, J
Ainsworth, MJ
Solanki, AK
Jones, JR
Allenby, MC
Stevens, M
Woodruff, MA
Item Type: Journal Article
Abstract: Additive manufacturing via melt electrowriting (MEW) can create ordered microfiber scaffolds relevant for bone tissue engineering; however, there remain limitations in the adoption of new printing materials, especially in MEW of biomaterials. For example, while promising composite formulations of polycaprolactone with strontium‐substituted bioactive glass have been processed into large or disordered fibres, from what is known, biologically‐relevant concentrations (>10 wt%) have never been printed into ordered microfibers using MEW. In this study, rheological characterization is used in combination with a predictive mathematical model to optimize biomaterial formulations and MEW conditions required to extrude various PCL and PCL/SrBG biomaterials to create ordered scaffolds. Previously, MEW printing of PCL/SrBG composites with 33 wt% glass required unachievable extrusion pressures. The composite formulation is modified using an evaporable solvent to reduce viscosity 100‐fold to fall within the predicted MEW pressure, temperature, and voltage tolerances, which enabled printing. This study reports the first fabrication of reproducible, ordered high‐content bioactive glass microfiber scaffolds by applying predictive modeling.
Issue Date: 1-Apr-2019
Date of Acceptance: 12-Mar-2019
URI: http://hdl.handle.net/10044/1/69118
DOI: https://dx.doi.org/10.1002/marc.201900019
ISSN: 1022-1336
Publisher: Wiley
Journal / Book Title: Macromolecular Rapid Communications
Copyright Statement: © 2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is the pre-peer reviewed version of the following article, which has been published in final form at https://onlinelibrary.wiley.com/doi/full/10.1002/marc.201900019
Keywords: additive manufacturing
bioactive glass
melt electrowriting
polycaprolactone
tissue engineering
03 Chemical Sciences
09 Engineering
Polymers
Publication Status: Published online
Embargo Date: 2020-04-01
Online Publication Date: 2019-04-01
Appears in Collections:Materials
Faculty of Natural Sciences



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Creative Commonsx